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Photoelectrochemical aptasensor based on nanocomposite of CdSe@SnS2 for ultrasensitive and selective detection of sulfamethazine

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Abstract

A photoelectrochemical (PEC) aptasensor based on CdSe@SnS2 nanocomposite has been developed to detect sulfamethazine (SMZ). The introduction of CdSe into SnS2 displayed an amplified PEC signal, which was higher than that of pure CdSe and SnS2, attributable to its enhanced light harvesting capacity and promoted PEC energy conversion efficiency. Due to the formation of specific non-covalent bonds, the SMZ-binding aptamer (SBA) has significant specificity and sensitivity. When SMZ was incubated on a CdSe@SnS2 modified electrode fixed with aminated SBA, the formation of the SMZ/SBA complex increased the space resistance of electron transfer and hindered the electronic migration between the electrodes, resulting in a decrease in photocurrent. The greater the adsorbed amount on the SBA, the lower the photocurrent produced.  Under optimized conditions the photocurrent response of MCH/SBA/CdSe@SnS2/FTO was inversely proportional to the SMZ concentration in the range 0.1 to 100 pM, with a detection limit (3 S/N) of 0.025 pM (at 0 V vs. Hg/HgCl). The recoveries ranged from 95.8 to 104% with relative standard deviations (RSDs) < 6.3% (n = 3) in actual water sample. This PEC aptasensor which shows considerable potential in SMZ detection applications has high selectivity, reproducibility, and good stability.

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Funding

This work was supported by the National Natural Science Foundation of China (No. 21905046, 52002068), the Natural Science Foundations of Guangdong Province (No. 2019A1515110315), the Guangdong Provincial Key Platform and Major Scientific Research Projects for Colleges and Universities (No. 2020KTSCX151), the Guangdong Provincial Key Construction Discipline Research Capacity Enhancement Project (No. 2021ZDJS088), and the Dongguan Science and Technology Commissioner Project (No. 20201800500172).

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Authors and Affiliations

  1. Guangdong Engineering and Technology Research Centre for Advanced Nanomaterials, School of Environment and Civil Engineering, Dongguan University of Technology, Dongguan, 523808, China

    Wenping Liu, Min Zhang, Lu’an Guo, Kefu Peng, Zu Man, Shilei Xie, Peng Liu, Dong Xie, Shoushan Wang & Faliang Cheng

  2. Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, 610054, China

    Lu’an Guo

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  1. Wenping Liu
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  2. Min Zhang
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Contributions

Wenping Liu: methodology, conceptualization, formal analysis, investigation, data curation, writing—original draft. Min Zhang: validation, writing—review & editing, project administration. Lu’an Guo: conceptualization, writing—review & editing. Kefu Peng: formal analysis, investigation. Zu Man: data curation. Shilei Xie: formal analysis. Peng Liu: resources. Dong Xie: funding acquisition. Shoushan Wang: project administration. Faliang Cheng: supervision, funding acquisition.

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Correspondence to Min Zhang or Faliang Cheng.

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Liu, W., Zhang, M., Guo, L. et al. Photoelectrochemical aptasensor based on nanocomposite of CdSe@SnS2 for ultrasensitive and selective detection of sulfamethazine. Microchim Acta 189, 453 (2022). https://doi.org/10.1007/s00604-022-05565-2

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