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NH2NH-MOF: a reaction matrix for the specific determination of small aldehydes by MALDI-MS

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Abstract

Efficient determination of aldehydes by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is hampered mainly by the low mass and unstable nature of analytes. In the present work, we propose a combined strategy of a reactive metal–organic framework (MOF) matrix for the derivatization and detection of aldehydes. A novel reactive MOF matrix (NH2NH-MOF) was synthesized in two steps. First, NR3+-MOF was synthesized via Cu2+ and the quaternary amine ligand 4,4′-bipyridinium, 1,1″-(1,2-ethanediyl)bis-, dibromide (PyEtBr). Then, -NHNH2 was introduced to NR3+-MOF through electrostatic adsorption between the -NR3+ and -HSO3− of 4-hydrazinylbenzenesulfonic acid to synthesize NH2NH-MOF. The acid–base chemistry of NH2NH-MOF led to uniform cocrystallization of the aldehyde-matrix mixtures and helped to achieve the detection of low-weight aldehydes with good relative standard deviations (RSDs = 0.07–12.35%). It was confirmed that this strategy can accurately quantify formaldehyde, valeraldehyde, and benzaldehyde with good linearity (r > 0.97). Furthermore, this strategy was applied to quantitatively detect benzaldehyde in wastewater, thus showing potential applications in environmental pollutant detection.

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Funding

Financial support was obtained from the National Natural Science Foundation of China (21874073) and the NCC Fund (NCC2020PY11).

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Authors and Affiliations

  1. Research Center for Analytical Science, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin, 300071, China

    Ruijuan Zheng, Yingchen Yang & Yan Xia

  2. Central Laboratory, Nankai University, Tianjin, 300071, China

    Yan Xia

Authors
  1. Ruijuan Zheng
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  2. Yingchen Yang
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  3. Yan Xia
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Correspondence to Yan Xia.

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Highlights

• NH2NH-MOF was synthesized, providing a new reactive matrix that possesses molecular recognition properties.

• Selective recognition of small aldehydes was achieved in complex samples with good accuracy.

• An MOF matrix was developed with built-in recognition capabilities, providing new ideas for the functional expansion of MOFs.

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Zheng, R., Yang, Y. & Xia, Y. NH2NH-MOF: a reaction matrix for the specific determination of small aldehydes by MALDI-MS. Microchim Acta 189, 51 (2022). https://doi.org/10.1007/s00604-021-05143-y

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