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Amperometric detection of antibiotic drug ciprofloxacin using cobalt-iron Prussian blue analogs capped on carbon nitride

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Abstract

Ciprofloxacin (CIP) electrochemical sensor was constructed using cobalt-iron Prussian blue analogs decorated on carbon nitride (Co-Fe-PBA@CN). Co-Fe-PBA decorated on CN was fabricated using a simple sonication-assisted hydrothermal method to prepare the composite to obtain a cube-shaped structure decorated on CN sheets. The fabricated Co-Fe-PBA@CN was physically characterized using XRD and SEM analysis. Then, the fabricated composite was electrochemically studied to sense antibiotic drug ciprofloxacin (CIP). The electrochemical behavior was investigated using tools such as cyclic voltammetry (CV) and amperometric I-t studies. The Co-Fe-PBA@CN modified electrode displays a wide linear range (0.005–300 and 325–741 μM) with a low detection limit (0.7389 and 1.0313 nM) and good sensitivity (0.3157 and 0.2263 μA.μM−1cm−2) toward CIP. The Co-Fe-PBA@CN modified electrode also exhibits good selectivity, reproducibility, and repeatability toward CIP. The proposed sensor was validated with real sample analysis, biological samples like urine and blood serum containing commercially available ciprofloxacin tablets were studied, and the results demonstrate good viability.

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Acknowledgements

We thank the National Taipei University of Technology for financial aid and laboratory facility. This work was supported by the Ministry of Science and Technology (Special Research Project-MOST-108-2221-E-027-063).

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  1. Department of Materials and Mineral Resources Engineering, National Taipei University of Technology, Taipei, Taiwan, Republic of China

    Narasimha Murthy Umesh, Jesu Amalraj Antolin Jesila & Sea-Fue Wang

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  1. Narasimha Murthy Umesh
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  2. Jesu Amalraj Antolin Jesila
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  3. Sea-Fue Wang
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Correspondence to Sea-Fue Wang.

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Umesh, N.M., Jesila, J.A.A. & Wang, SF. Amperometric detection of antibiotic drug ciprofloxacin using cobalt-iron Prussian blue analogs capped on carbon nitride. Microchim Acta 189, 31 (2022). https://doi.org/10.1007/s00604-021-05061-z

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