Abstract
Human epidermal growth factor receptor 2 (HER2) is one of the key molecular targets in breast cancer pathogenesis. Overexpression and/or amplification of HER2 in approximately 15–20% of breast cancer patients is associated with high mortality and poor prognosis. Accumulating evidence shows that accurate and sensitive detection of HER2 improves the survival outcomes for HER2-positive breast cancer patients from targeted therapies. The current methods of clinical determination of HER2 expression levels are based on slide-based assays that rely on invasively collected primary tumours. Alternatively, ELISA-based detection of the shredded HER2 extracellular domain (HER2-ECD) of has been suggested as a surrogate method for monitoring disease progress and treatment response in breast cancer patients. In the past decade, biosensors have emerged as an alternative modality for the detection of circulating HER2-ECD in human serum samples. In particular, electrochemical biosensors based on nanomaterials and antibodies and aptamers have been increasingly developed as promising tools for rapid, sensitive, and cost-effective detection of HER2-ECD. These biosensors harness the high affinity and specificity of antibodies and aptamers, and unique conductive properties, biocompatibility, large surface area, and chemical stability of nanomaterials for selective and sensitive assessment of the HER2. This review provides an overview of the recent advances in the application of nanomaterials-based immunosensors and aptasensors for detection of circulating HER2-ECD. In particular, various electrochemical techniques, detection approaches, and nanomaterials are discussed. Further, analytical figures of merit of various HER2 immunosensors and aptasensors are compared. Finally, possible challenges and potential opportunities for biosensor-based detection of HER2-ECD are discussed.
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Aleskandarany MA, Vandenberghe ME, Marchiò C, Ellis IO, Sapino A, Rakha EA (2018) Tumour heterogeneity of breast cancer: from morphology to personalised medicine. Pathobiology 85(1–2):23–34. https://doi.org/10.1159/000477851
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–249. https://doi.org/10.3322/caac.21660
Andre F, Pusztai L (2006) Molecular classification of breast cancer: implications for selection of adjuvant chemotherapy. Nat Clin Pract Oncol 3(11):621–632. https://doi.org/10.1038/ncponc0636
Garmpis N, Damaskos C, Garmpi A, Nikolettos K, Dimitroulis D, Diamantis E, Farmaki P, Patsouras A, Voutyritsa E, Syllaios A, Zografos CG, Antoniou EA, Nikolettos N, Kostakis A, Kontzoglou K, Schizas D, Nonni A (2020) Molecular classification and future therapeutic challenges of triple-negative breast Cancer. In vivo 34(4):1715. https://doi.org/10.21873/invivo.11965
Prat A, Chaudhury A, Solovieff N, Paré L, Martinez D, Chic N, Martínez-Sáez O, Brasó-Maristany F, Lteif A, Taran T, Babbar N, Su F (2021) Correlative biomarker analysis of intrinsic subtypes and efficacy across the MONALEESA phase III studies. J Clin Oncol 39:1458–1467. https://doi.org/10.1200/jco.20.02977
Waks AG, Winer EP (2019) Breast cancer treatment: a review. JAMA 321(3):288–300. https://doi.org/10.1001/jama.2018.19323
Prenzel N, Fischer OM, Streit S, Hart S, Ullrich A (2001) The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification. Endocr Relat Cancer 8(1):11–31. https://doi.org/10.1677/erc.0.0080011
Yarden Y, Sliwkowski MX (2001) Untangling the ErbB signalling network. Nat Rev Mol Cell Biol 2(2):127–137. https://doi.org/10.1038/35052073
Moasser MM (2007) The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis. Oncogene 26(45):6469–6487. https://doi.org/10.1038/sj.onc.1210477
Gabos Z, Sinha R, Hanson J, Chauhan N, Hugh J, Mackey JR, Abdulkarim B (2006) Prognostic significance of human epidermal growth factor receptor positivity for the development of brain metastasis after newly diagnosed breast cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 24(36):5658–5663. https://doi.org/10.1200/jco.2006.07.0250
Arteaga CL, Sliwkowski MX, Osborne CK, Perez EA, Puglisi F, Gianni L (2011) Treatment of HER2-positive breast cancer: current status and future perspectives. Nat Rev Clin Oncol 9(1):16–32. https://doi.org/10.1038/nrclinonc.2011.177
Wang J, Xu B (2019) Targeted therapeutic options and future perspectives for HER2-positive breast cancer. Signal Transduction and Targeted Therapy 4(1):34. https://doi.org/10.1038/s41392-019-0069-2
Wolff AC, Hammond MEH, Allison KH, Harvey BE, Mangu PB, Bartlett JMS, Bilous M, Ellis IO, Fitzgibbons P, Hanna W, Jenkins RB, Press MF, Spears PA, Vance GH, Viale G, McShane LM, Dowsett M (2018) Human epidermal growth factor receptor 2 testing in breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Focused Update. Arch Pathol Lab Med 142(11):1364–1382. https://doi.org/10.5858/arpa.2018-0902-SA
Wolff AC, Hammond MEH, Hicks DG, Dowsett M, McShane LM, Allison KH, Allred DC, Bartlett JMS, Bilous M, Fitzgibbons P, Hanna W, Jenkins RB, Mangu PB, Paik S, Perez EA, Press MF, Spears PA, Vance GH, Viale G, Hayes DF (2014) Recommendations for human epidermal growth factor receptor 2 testing in breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Update. Arch Pathol Lab Med 138(2):241–256. https://doi.org/10.5858/arpa.2013-0953-SA
Shah S, Chen B (2011) Testing for HER2 in breast cancer: a continuing evolution. Pathol Res Int 2011:903202–903216. https://doi.org/10.4061/2011/903202
Hanna WM, Kwok K (2006) Chromogenic in-situ hybridization: a viable alternative to fluorescence in-situ hybridization in the HER2 testing algorithm. Mod Pathol 19(4):481–487. https://doi.org/10.1038/modpathol.3800555
Wesoła M, Jeleń M (2015) A comparison of IHC and FISH cytogenetic methods in the evaluation of HER2 status in breast Cancer. Advances in clinical and experimental medicine : official organ Wroclaw Medical University 24(5):899–903. https://doi.org/10.17219/acem/27923
FDA (2021) List of Cleared or Approved Companion Diagnostic Devices (In Vitro and Imaging Tools). Food and Drug Administration. https://www.fda.gov/medical-devices/in-vitro-diagnostics/list-cleared-or-approved-companion-diagnostic-devices-in-vitro-and-imaging-tools. Accessed 7 April 2021 2021
Ross JS, Symmans WF, Pusztai L, Hortobagyi GN (2007) Standardizing slide-based assays in breast cancer: hormone receptors, HER2, and sentinel lymph nodes. Clin Cancer Res 13(10):2831–2835. https://doi.org/10.1158/1078-0432.ccr-06-2522
Bogen SA (2019) A root cause analysis into the high error rate in clinical immunohistochemistry. Appl Immunohistochem Mol Morphol 27(5):329–338. https://doi.org/10.1097/pai.0000000000000750
Laurinavicius A, Plancoulaine B, Herlin P, Laurinaviciene A (2016) Comprehensive immunohistochemistry: digital, analytical and integrated. Pathobiology 83(2–3):156–163. https://doi.org/10.1159/000442389
Molina R, Augé JM, Escudero JM, Filella X, Zanon G, Pahisa J, Farrus B, Muñoz M, Velasco M (2010) Evaluation of tumor markers (HER-2/neu oncoprotein, CEA, and CA 15.3) in patients with locoregional breast cancer: prognostic value. Tumor Biol 31(3):171–180. https://doi.org/10.1007/s13277-010-0025-9
Carney WP, Neumann R, Lipton A, Leitzel K, Ali S, Price CP (2004) Monitoring the circulating levels of the HER2/neu Oncoprotein in breast cancer. Clinical Breast Cancer 5(2):105–116. https://doi.org/10.3816/CBC.2004.n.014
Fehm T, Gebauer G, Jäger W (2002) Clinical utility of serial serum c-erbB-2 determinations in the follow-up of breast cancer patients. Breast Cancer Res Treat 75(2):97–106. https://doi.org/10.1023/a:1019601022456
Dittadi R, Zancan M, Perasole A, Gion M (2001) Evaluation of HER-2/neu in serum and tissue of primary and metastatic breast cancer patients using an automated enzyme immunoassay. Int J Biol Markers 16(4):255–261
A-S GAUCHEZ, RAVANEL N, VILLEMAIN D, F-X BRAND, PASQUIER D, PAYAN R, MOUSSEAU M (2008) Evaluation of a manual ELISA kit for determination of HER2/neu in serum of breast cancer patients. Anticancer Res 28(5B):3067–3073
Shamshirian A, Aref AR, Yip GW, Ebrahimi Warkiani M, Heydari K, Razavi Bazaz S, Hamzehgardeshi Z, Shamshirian D, Moosazadeh M, Alizadeh-Navaei R (2020) Diagnostic value of serum HER2 levels in breast cancer: a systematic review and meta-analysis. BMC Cancer 20(1):1049. https://doi.org/10.1186/s12885-020-07545-2
Zoppoli G, Garuti A, Cirmena G, di Cantogno LV, Botta C, Gallo M, Ferraioli D, Carminati E, Baccini P, Curto M, Fregatti P, Isnaldi E, Lia M, Murialdo R, Friedman D, Sapino A, Ballestrero A (2017) Her2 assessment using quantitative reverse transcriptase polymerase chain reaction reliably identifies Her2 overexpression without amplification in breast cancer cases. J Transl Med 15(1):91. https://doi.org/10.1186/s12967-017-1195-7
Şahin S, Caglayan MO, Üstündağ Z (2020) Recent advances in aptamer-based sensors for breast cancer diagnosis: special cases for nanomaterial-based VEGF, HER2, and MUC1 aptasensors. Microchim Acta 187(10):549. https://doi.org/10.1007/s00604-020-04526-x
Xiang W, Lv Q, Shi H, Xie B, Gao L (2020) Aptamer-based biosensor for detecting carcinoembryonic antigen. Talanta 214:120716. https://doi.org/10.1016/j.talanta.2020.120716
Dehghani S, Nosrati R, Yousefi M, Nezami A, Soltani F, Taghdisi SM, Abnous K, Alibolandi M, Ramezani M (2018) Aptamer-based biosensors and nanosensors for the detection of vascular endothelial growth factor (VEGF): a review. Biosens Bioelectron 110:23–37. https://doi.org/10.1016/j.bios.2018.03.037
Yousefi M, Dehghani S, Nosrati R, Zare H, Evazalipour M, Mosafer J, Tehrani BS, Pasdar A, Mokhtarzadeh A, Ramezani M (2019) Aptasensors as a new sensing technology developed for the detection of MUC1 mucin: a review. Biosens Bioelectron 130:1–19. https://doi.org/10.1016/j.bios.2019.01.015
Peng H-P, Lee KH, Jian J-W, Yang A-S (2014) Origins of specificity and affinity in antibody–protein interactions. Proc Natl Acad Sci 111(26):E2656–E2665. https://doi.org/10.1073/pnas.1401131111
Frejd FY, Kim KT (2017) Affibody molecules as engineered protein drugs. Exp Mol Med 49(3):e306. https://doi.org/10.1038/emm.2017.35
Song S, Wang L, Li J, Fan C, Zhao J (2008) Aptamer-based biosensors. TrAC Trends Anal Chem 27(2):108–117. https://doi.org/10.1016/j.trac.2007.12.004
Iliuk AB, Hu L, Tao WA (2011) Aptamer in bioanalytical applications. Anal Chem 83(12):4440–4452. https://doi.org/10.1021/ac201057w
Ahirwar R, Dalal A, Sharma JG, Yadav BK, Nahar P, Kumar A, Kumar S (2019) An aptasensor for rapid and sensitive detection of estrogen receptor alpha in human breast cancer. Biotechnol Bioeng 116(1):227–233. https://doi.org/10.1002/bit.26819
Ahirwar R, Nahar P (2015) Development of an aptamer-affinity chromatography for efficient single step purification of Concanavalin A from Canavalia ensiformis. J Chromatogr B Anal Technol Biomed Life Sci 997:105–109. https://doi.org/10.1016/j.jchromb.2015.06.003
Ahirwar R, Nahar P (2015) Screening and identification of a DNA aptamer to concanavalin A and its application in food analysis. J Agric Food Chem 63(16):4104–4111. https://doi.org/10.1021/acs.jafc.5b00784
Ahirwar R, Vellarikkal SK, Sett A, Sivasubbu S, Scaria V, Bora U, Borthakur BB, Kataki AC, Sharma JD, Nahar P (2016) Aptamer-assisted detection of the altered expression of estrogen receptor alpha in human breast cancer. PLoS One 11(4):e0153001. https://doi.org/10.1371/journal.pone.0153001
Wang Y-H, He L-L, Huang K-J, Chen Y-X, Wang S-Y, Liu Z-H, Li D (2019) Recent advances in nanomaterial-based electrochemical and optical sensing platforms for microRNA assays. Analyst 144(9):2849–2866. https://doi.org/10.1039/C9AN00081J
Ahirwar R, Khan N, Kumar S (2021) Aptamer-based sensing of breast cancer biomarkers: a comprehensive review of analytical figures of merit. Expert Rev Mol Diagn 21(7):703–721. https://doi.org/10.1080/14737159.2021.1920397
Ou D, Sun D, Lin X, Liang Z, Zhong Y, Chen Z (2019) A dual-aptamer-based biosensor for specific detection of breast cancer biomarker HER2 via flower-like nanozymes and DNA nanostructures. J Mater Chem B 7(23):3661–3669. https://doi.org/10.1039/C9TB00472F
Yang S, You M, Zhang F, Wang Q, He P (2018) A sensitive electrochemical aptasensing platform based on exonuclease recycling amplification and host-guest recognition for detection of breast cancer biomarker HER2. Sensors Actuators B Chem 258:796–802. https://doi.org/10.1016/j.snb.2017.11.119
Arya SK, Zhurauski P, Jolly P, Batistuti MR, Mulato M, Estrela P (2018) Capacitive aptasensor based on interdigitated electrode for breast cancer detection in undiluted human serum. Biosens Bioelectron 102:106–112. https://doi.org/10.1016/j.bios.2017.11.013
Bezerra G, Córdula C, Campos D, Nascimento G, Oliveira N, Seabra MA, Visani V, Lucas S, Lopes I, Santos J, Xavier F, Borba MA, Martins D, Lima-Filho J (2019) Electrochemical aptasensor for the detection of HER2 in human serum to assist in the diagnosis of early stage breast cancer. Anal Bioanal Chem 411(25):6667–6676. https://doi.org/10.1007/s00216-019-02040-5
Guo X, Liu S, Yang M, Du H, Qu F (2019) Dual signal amplification photoelectrochemical biosensor for highly sensitive human epidermal growth factor receptor-2 detection. Biosens Bioelectron 139:111312. https://doi.org/10.1016/j.bios.2019.05.017
Ilkhani H, Sarparast M, Noori A, Zahra Bathaie S, Mousavi MF (2015) Electrochemical aptamer/antibody based sandwich immunosensor for the detection of EGFR, a cancer biomarker, using gold nanoparticles as a signaling probe. Biosens Bioelectron 74:491–497. https://doi.org/10.1016/j.bios.2015.06.063
Chun L, Kim S-E, Cho M, W-s C, Nam J, Lee DW, Lee Y (2013) Electrochemical detection of HER2 using single stranded DNA aptamer modified gold nanoparticles electrode. Sensors Actuators B Chem 186:446–450. https://doi.org/10.1016/j.snb.2013.06.046
Qureshi A, Gurbuz Y, Niazi JH (2015) Label-free capacitance based aptasensor platform for the detection of HER2/ErbB2 cancer biomarker in serum. Sensors Actuators B Chem 220:1145–1151. https://doi.org/10.1016/j.snb.2015.06.094
Rostamabadi PF, Heydari-Bafrooei E (2019) Impedimetric aptasensing of the breast cancer biomarker HER2 using a glassy carbon electrode modified with gold nanoparticles in a composite consisting of electrochemically reduced graphene oxide and single-walled carbon nanotubes. Microchim Acta 186(8):495. https://doi.org/10.1007/s00604-019-3619-y
Zhou N, Su F, Li Z, Yan X, Zhang C, Hu B, He L, Wang M, Zhang Z (2019) Gold nanoparticles conjugated to bimetallic manganese(II) and iron(II) Prussian Blue analogues for aptamer-based impedimetric determination of the human epidermal growth factor receptor-2 and living MCF-7 cells. Microchim Acta 186(2):75. https://doi.org/10.1007/s00604-018-3184-9
Salimian R, Kékedy-Nagy L, Ferapontova EE (2017) Specific picomolar detection of a breast cancer biomarker HER-2/neu protein in serum: electrocatalytically amplified electroanalysis by the aptamer/PEG-modified electrode. ChemElectroChem 4(4):872–879. https://doi.org/10.1002/celc.201700025
Shen C, Zeng K, Luo J, Li X, Yang M, Rasooly A (2017) Self-assembled DNA generated electric current biosensor for HER2 analysis. Anal Chem 89(19):10264–10269. https://doi.org/10.1021/acs.analchem.7b01747
Luo J, Liang D, Qiu X, Yang M (2019) Photoelectrochemical detection of breast cancer biomarker based on hexagonal carbon nitride tubes. Anal Bioanal Chem 411(26):6889–6897. https://doi.org/10.1007/s00216-019-02060-1
Chai Y, Li X, Yang M (2019) Aptamer based determination of the cancer biomarker HER2 by using phosphate-functionalized MnO2 nanosheets as the electrochemical probe. Microchim Acta 186(5):316. https://doi.org/10.1007/s00604-019-3412-y
Hu L, Hu S, Guo L, Shen C, Yang M, Rasooly A (2017) DNA generated electric current biosensor. Anal Chem 89(4):2547–2552. https://doi.org/10.1021/acs.analchem.6b04756
Tabasi A, Noorbakhsh A, Sharifi E (2017) Reduced graphene oxide-chitosan-aptamer interface as new platform for ultrasensitive detection of human epidermal growth factor receptor 2. Biosens Bioelectron 95:117–123. https://doi.org/10.1016/j.bios.2017.04.020
Gu C, Guo C, Li Z, Wang M, Zhou N, He L, Zhang Z, Du M (2019) Bimetallic ZrHf-based metal-organic framework embedded with carbon dots: ultra-sensitive platform for early diagnosis of HER2 and HER2-overexpressed living cancer cells. Biosens Bioelectron 134:8–15. https://doi.org/10.1016/j.bios.2019.03.043
Zhu Y, Chandra P, Shim Y-B (2013) Ultrasensitive and selective electrochemical diagnosis of breast cancer based on a hydrazine–Au nanoparticle–aptamer bioconjugate. Anal Chem 85(2):1058–1064. https://doi.org/10.1021/ac302923k
Ferreira DC, Batistuti MR, Bachour B, Mulato M (2021) Aptasensor based on screen-printed electrode for breast cancer detection in undiluted human serum. Bioelectrochemistry 137:107586. https://doi.org/10.1016/j.bioelechem.2020.107586
Bhalla N, Jolly P, Formisano N, Estrela P (2016) Introduction to biosensors. Essays Biochem 60(1):1–8. https://doi.org/10.1042/ebc20150001
Liu H, Ge J, Ma E, Yang L (2019) Advanced biomaterials for biosensor and theranostics. In: Yang L, Bhaduri SB, Webster TJ (eds) Biomaterials in Translational Medicine. Academic Press, pp 213–255. https://doi.org/10.1016/B978-0-12-813477-1.00010-4
Sawant SN (2017) Development of biosensors from biopolymer composites. In: Sadasivuni KK, Ponnamma D, Kim J, Cabibihan JJ, MA AM (eds) Biopolymer Composites in Electronics. Elsevier, pp 353–383. https://doi.org/10.1016/B978-0-12-809261-3.00013-9
Grieshaber D, MacKenzie R, Vörös J, Reimhult E (2008) Electrochemical biosensors — sensor principles and architectures. Sensors 8(3):1400–1458
Taleat Z, Khoshroo A, Mazloum-Ardakani M (2014) Screen-printed electrodes for biosensing: a review (2008–2013). Microchim Acta 181(9):865–891. https://doi.org/10.1007/s00604-014-1181-1
Hussain G, Silvester DS (2018) Comparison of voltammetric techniques for ammonia sensing in ionic liquids. Electroanalysis 30(1):75–83. https://doi.org/10.1002/elan.201700555
Bahadır EB, Sezgintürk MK (2016) A review on impedimetric biosensors. Artificial Cells, Nanomedicine, and Biotechnology 44(1):248–262. https://doi.org/10.3109/21691401.2014.942456
Kounaves SP (1997) Voltammetric techniques. In: Settle FA (ed) Handbook of instrumental techniques for analytical chemistry. Prentice Hall, Upper Saddle River, pp 709–725
Simões FR, Xavier MG (2017) Electrochemical sensors. In: Da Róz AL, Ferreira M, de Lima Leite F, Oliveira ON (eds) Nanoscience and its Applications. William Andrew Publishing, pp 155–178. https://doi.org/10.1016/B978-0-323-49780-0.00006-5
Islam MN, Channon RB (2020) Electrochemical sensors. In: Ladame S, JYH C (eds) Bioengineering Innovative Solutions for Cancer. Academic Press, pp 47–71. https://doi.org/10.1016/B978-0-12-813886-1.00004-8
Mirceski V, Guziejewski D, Stojanov L, Gulaboski R (2019) Differential square-wave voltammetry. Anal Chem 91(23):14904–14910. https://doi.org/10.1021/acs.analchem.9b03035
Osteryoung JG, Osteryoung RA (1985) Square wave voltammetry. Anal Chem 57(1):101–110. https://doi.org/10.1021/ac00279a004
Lisdat F, Schäfer D (2008) The use of electrochemical impedance spectroscopy for biosensing. Anal Bioanal Chem 391(5):1555–1567. https://doi.org/10.1007/s00216-008-1970-7
Bogomolova A, Komarova E, Reber K, Gerasimov T, Yavuz O, Bhatt S, Aldissi M (2009) Challenges of electrochemical impedance spectroscopy in protein biosensing. Anal Chem 81(10):3944–3949. https://doi.org/10.1021/ac9002358
Ravalli A, da Rocha CG, Yamanaka H, Marrazza G (2015) A label-free electrochemical affisensor for cancer marker detection: the case of HER2. Bioelectrochemistry 106:268–275. https://doi.org/10.1016/j.bioelechem.2015.07.010
Chen D, Wang D, Hu X, Long G, Zhang Y, Zhou L (2019) A DNA nanostructured biosensor for electrochemical analysis of HER2 using bioconjugate of GNR@Pd SSs—Apt—HRP. Sensors Actuators B Chem 296:126650. https://doi.org/10.1016/j.snb.2019.126650
Freitas M, Nouws HPA, Delerue-Matos C (2019) Electrochemical sensing platforms for HER2-ECD breast cancer biomarker detection. Electroanalysis 31(1):121–128. https://doi.org/10.1002/elan.201800537
Freitas M, Neves MMPS, Nouws HPA, Delerue-Matos C (2020) Quantum dots as nanolabels for breast cancer biomarker HER2-ECD analysis in human serum. Talanta 208:120430. https://doi.org/10.1016/j.talanta.2019.120430
Shen C, Liu S, Li X, Zhao D, Yang M (2018) Immunoelectrochemical detection of the human epidermal growth factor receptor 2 (HER2) via gold nanoparticle-based rolling circle amplification. Microchim Acta 185(12):547. https://doi.org/10.1007/s00604-018-3086-x
Li X, Shen C, Yang M, Rasooly A (2018) Polycytosine DNA electric-current-generated Immunosensor for electrochemical detection of human epidermal growth factor receptor 2 (HER2). Anal Chem 90(7):4764–4769. https://doi.org/10.1021/acs.analchem.8b00023
Shen C, Li X, Rasooly A, Guo L, Zhang K, Yang M (2016) A single electrochemical biosensor for detecting the activity and inhibition of both protein kinase and alkaline phosphatase based on phosphate ions induced deposition of redox precipitates. Biosens Bioelectron 85:220–225. https://doi.org/10.1016/j.bios.2016.05.025
Xie S, Yuan Y, Chai Y, Yuan R (2015) Tracing phosphate ions generated during loop-mediated isothermal amplification for electrochemical detection of Nosema bombycis genomic DNA PTP1. Anal Chem 87(20):10268–10274. https://doi.org/10.1021/acs.analchem.5b01858
Maiti D, Tong X, Mou X, Yang K (2019) Carbon-based nanomaterials for biomedical applications: a recent study. Front Pharmacol 9(1401). https://doi.org/10.3389/fphar.2018.01401
Rocha-Santos TAP (2014) Sensors and biosensors based on magnetic nanoparticles. TrAC Trends Anal Chem 62:28–36. https://doi.org/10.1016/j.trac.2014.06.016
Malekzad H, Zangabad PS, Mirshekari H, Karimi M, Hamblin MR (2017) Noble metal nanoparticles in biosensors: recent studies and applications. Nanotechnol Rev 6(3):301–329. https://doi.org/10.1515/ntrev-2016-0014
Shan H, Li X, Liu L, Song D, Wang Z (2020) Recent advances in nanocomposite-based electrochemical aptasensors for the detection of toxins. J Mater Chem B 8(27):5808–5825. https://doi.org/10.1039/D0TB00705F
Malhotra BD, Ali MA (2018) Nanomaterials in biosensors: fundamentals and applications. Nanomaterials for Biosensors:1–74. https://doi.org/10.1016/B978-0-323-44923-6.00001-7
Biju V (2014) Chemical modifications and bioconjugate reactions of nanomaterials for sensing, imaging, drug delivery and therapy. Chem Soc Rev 43(3):744–764. https://doi.org/10.1039/c3cs60273g
Xue Y, Li X, Li H, Zhang W (2014) Quantifying thiol–gold interactions towards the efficient strength control. Nat Commun 5(1):4348. https://doi.org/10.1038/ncomms5348
Hartati YW, Letelay LK, Gaffar S, Wyantuti S, Bahti HH (2020) Cerium oxide-monoclonal antibody bioconjugate for electrochemical immunosensing of HER2 as a breast cancer biomarker. Sensing and Bio-Sensing Research 27:100316. https://doi.org/10.1016/j.sbsr.2019.100316
Ortega FG, Piguillem SV, Messina GA, Tortella GR, Rubilar O, Jiménez Castillo MI, Lorente JA, Serrano MJ, Raba J, Fernández Baldo MA (2019) EGFR detection in extracellular vesicles of breast cancer patients through immunosensor based on silica-chitosan nanoplatform. Talanta 194:243–252. https://doi.org/10.1016/j.talanta.2018.10.016
Duan D, Yang H, Ding Y, Ye D, Li L, Ma G (2018) Three-dimensional molecularly imprinted electrochemical sensor based on Au NPs@Ti-based metal-organic frameworks for ultra-trace detection of bovine serum albumin. Electrochim Acta 261:160–166. https://doi.org/10.1016/j.electacta.2017.12.146
Falcaro P, Ricco R, Yazdi A, Imaz I, Furukawa S, Maspoch D, Ameloot R, Evans JD, Doonan CJ (2016) Application of metal and metal oxide nanoparticles@MOFs. Coord Chem Rev 307:237–254. https://doi.org/10.1016/j.ccr.2015.08.002
Emami M, Shamsipur M, Saber R, Irajirad R (2014) An electrochemical immunosensor for detection of a breast cancer biomarker based on antiHER2–iron oxide nanoparticle bioconjugates. Analyst 139(11):2858–2866. https://doi.org/10.1039/C4AN00183D
Ehzari H, Samimi M, Safari M, Gholivand MB (2020) Label-free electrochemical immunosensor for sensitive HER2 biomarker detection using the core-shell magnetic metal-organic frameworks. J Electroanal Chem 877:114722. https://doi.org/10.1016/j.jelechem.2020.114722
Battigelli A, Ménard-Moyon C, Da Ros T, Prato M, Bianco A (2013) Endowing carbon nanotubes with biological and biomedical properties by chemical modifications. Adv Drug Deliv Rev 65(15):1899–1920. https://doi.org/10.1016/j.addr.2013.07.006
Arkan E, Saber R, Karimi Z, Shamsipur M (2015) A novel antibody-antigen based impedimetric immunosensor for low level detection of HER2 in serum samples of breast cancer patients via modification of a gold nanoparticles decorated multiwall carbon nanotube-ionic liquid electrode. Anal Chim Acta 874:66–74. https://doi.org/10.1016/j.aca.2015.03.022
Liu B, Liu J (2015) Accelerating peroxidase mimicking nanozymes using DNA. Nanoscale 7(33):13831–13835. https://doi.org/10.1039/C5NR04176G
Boriachek K, Islam MN, Gopalan V, Lam AK, Nguyen N-T, Shiddiky MJA (2017) Quantum dot-based sensitive detection of disease specific exosome in serum. Analyst 142(12):2211–2219. https://doi.org/10.1039/C7AN00672A
Freitas M, Nouws HPA, Keating E, Fernandes VC, Delerue-Matos C (2020) Immunomagnetic bead-based bioassay for the voltammetric analysis of the breast cancer biomarker HER2-ECD and tumour cells using quantum dots as detection labels. Microchim Acta 187(3):184. https://doi.org/10.1007/s00604-020-4156-4
Shah VP, Midha KK, Dighe S, McGilveray IJ, Skelly JP, Yacobi A, Layloff T, Viswanathan CT, Cook CE, McDowall RD, Pittman KA, Spector S (1992) Analytical methods validation: bioavailability, bioequivalence, and pharmacokinetic studies. J Pharm Sci 81(3):309–312. https://doi.org/10.1002/jps.2600810324
Zhang Z, Li C, Fan H, Xiang Q, Xu L, Liu Q, Zhou S, Xie Q, Chen S, Mu G, Cui Y (2018) Prognostic value of baseline serum HER2 extracellular domain level with a cut-off value of 15 ng/mL in patients with breast cancer: a systematic review and meta-analysis. Breast Cancer Res Treat 172(3):513–521. https://doi.org/10.1007/s10549-018-4942-4
Patris S, De Pauw P, Vandeput M, Huet J, Van Antwerpen P, Muyldermans S, Kauffmann J-M (2014) Nanoimmunoassay onto a screen printed electrode for HER2 breast cancer biomarker determination. Talanta 130:164–170. https://doi.org/10.1016/j.talanta.2014.06.069
Marques RC, Viswanathan S, Nouws HP, Delerue-Matos C, González-García MB (2014) Electrochemical immunosensor for the analysis of the breast cancer biomarker HER2 ECD. Talanta 129:594–599. https://doi.org/10.1016/j.talanta.2014.06.035
Marques RCB, Costa-Rama E, Viswanathan S, Nouws HPA, Costa-García A, Delerue-Matos C, González-García MB (2018) Voltammetric immunosensor for the simultaneous analysis of the breast cancer biomarkers CA 15-3 and HER2-ECD. Sensors Actuators B Chem 255:918–925. https://doi.org/10.1016/j.snb.2017.08.107
Yola ML (2021) Sensitive sandwich-type voltammetric immunosensor for breast cancer biomarker HER2 detection based on gold nanoparticles decorated Cu-MOF and Cu2ZnSnS4 NPs/Pt/g-C3N4 composite. Microchim Acta 188(3):78. https://doi.org/10.1007/s00604-021-04735-y
Tallapragada SD, Layek K, Mukherjee R, Mistry KK, Ghosh M (2017) Development of screen-printed electrode based immunosensor for the detection of HER2 antigen in human serum samples. Bioelectrochemistry 118:25–30. https://doi.org/10.1016/j.bioelechem.2017.06.009
Wang X-Y, Feng Y-G, Wang A-J, Mei L-P, Yuan P-X, Luo X, Feng J-J (2021) A facile ratiometric electrochemical strategy for ultrasensitive monitoring HER2 using polydopamine-grafted-ferrocene/reduced graphene oxide, au@ag nanoshuttles and hollow Ni@PtNi yolk-shell nanocages. Sensors Actuators B Chem 331:129460. https://doi.org/10.1016/j.snb.2021.129460
Shamsipur M, Emami M, Farzin L, Saber R (2018) A sandwich-type electrochemical immunosensor based on in situ silver deposition for determination of serum level of HER2 in breast cancer patients. Biosens Bioelectron 103:54–61. https://doi.org/10.1016/j.bios.2017.12.022
Lah ZMANH, Ahmad SAA, Zaini MS, Kamarudin MA (2019) An electrochemical sandwich immunosensor for the detection of HER2 using antibody-conjugated PbS quantum dot as a label. J Pharm Biomed Anal 174:608–617. https://doi.org/10.1016/j.jpba.2019.06.024
Sharma S, Zapatero-Rodríguez J, Saxena R, O'Kennedy R, Srivastava S (2018) Ultrasensitive direct impedimetric immunosensor for detection of serum HER2. Biosens Bioelectron 106:78–85. https://doi.org/10.1016/j.bios.2018.01.056
Mori S, Mori Y, Mukaiyama T, Yamada Y, Sonobe Y, Matsushita H, Sakamoto G, Akiyama T, Ogawa M, Shiraishi M, Toyoshima K, Yamamoto T (1990) In vitro and in vivo release of soluble erbB-2 protein from human carcinoma cells. Japanese journal of cancer research : Gann 81(5):489–494. https://doi.org/10.1111/j.1349-7006.1990.tb02596.x
Molina R, Jo J, Filella X, Zanón G, Farrus B, Muñoz M, Latre ML, Pahisa J, Velasco M, Fernandez P, Estapé J, Ballesta AM (1999) C-erbB-2, CEA and CA 15.3 serum levels in the early diagnosis of recurrence of breast cancer patients. Anticancer Res 19(4a):2551–2555
Krainer M, Brodowicz T, Zeillinger R, Wiltschke C, Scholten C, Seifert M, Kubista E, Zielinski CC (1997) Tissue expression and serum levels of HER-2/neu in patients with breast cancer. Oncology 54(6):475–481. https://doi.org/10.1159/000227606
Acknowledgements
The author thanks the Indian Council of Medical Research and Science and Engineering Research Board, Govt. of India for financially supporting the study. The author also thanks Mrs. Kamini Arya and Mr. Nabab Khan for their help in data collection.
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Research in the laboratory of the corresponding author is supported by funds from the Indian Council of Medical Research (65/2/AKT/NIREH/2018-NCD-II) and Science and Engineering Research Board (ECR/2017/003179).
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Ahirwar, R. Recent advances in nanomaterials-based electrochemical immunosensors and aptasensors for HER2 assessment in breast cancer. Microchim Acta 188, 317 (2021). https://doi.org/10.1007/s00604-021-04963-2
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DOI: https://doi.org/10.1007/s00604-021-04963-2