A sensitive and selective molecular imprinted polymeric network (MIP) electrochemical sensor is proposed for the determination of anti-cancer drug oxaliplatin (OXAL). The polymeric network [poly(pyrrole)] was electrodeposited on a glassy carbon electrode (GCE) modified with silver nanoparticles (Ag) functionalized Cu-metal organic framework (Cu-BDC) and nitrogen-doped carbon nanotubes (N-CNTs). The MIP-Ag@Cu-BDC /N-CNTs/GCE showed an observable reduction peak at −0.14 V, which corresponds to the Cu-BDC reduction. This peak increased and decreased by eluting and rebinding of OXAL, respectively. The binding constant between OXAL and Cu-BDC was calculated to be 3.5 ± 0.1 × 107 mol−1 L. The electrochemical signal (∆i) increased with increasing OXAL concentration in the range 0.056–200 ng mL−1 with a limit of detection (LOD, S/N = 3) of 0.016 ng mL−1. The combination of N-CNTs and Ag@Cu-BDC improves both the conductivity and the anchoring sites for binding the polymer film on the surface of the electrode. The MIP-based electrochemical sensor offered outstanding sensitivity, selectivity, reproducibility, and stability. The MIP-Ag@Cu-BDC /N-CNTs/GCE was applied to determine OXAL in pharmaceutical injections, human plasma, and urine samples with good recoveries (97.5–105%) and acceptable relative standard deviations (RSDs = 1.8–3.2%). Factors affecting fabrication of MIP and OXAL determination were optimized using standard orthogonal design using L25 (56) matrix. This MIP based electrochemical sensor opens a new venue for the fabrication of other similar sensors and biosensors.
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The authors extend their appreciation to the Deputyship for Research & Innovation, “Ministry of Education” in Saudi Arabia for funding this research work through the project no. (IFKSURG-295)”.
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The original online version of this article was revised: In this article the affiliation details for "Ali Mohammed Alaseem" and "Mohammad M. Algahtani" were incorrectly given as "Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia" and "Pharmacology department, College of Medicine, Al Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia". It should have been "Department of Pharmacology, College of Medicine, Al Imam Mohammad Ibn Saud Islamic University, Riyadh,Saudi Arabia" and "Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
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Mahnashi, M.H., Mahmoud, A.M., Alhazzani, K. et al. Ultrasensitive and selective molecularly imprinted electrochemical oxaliplatin sensor based on a novel nitrogen-doped carbon nanotubes/Ag@cu MOF as a signal enhancer and reporter nanohybrid. Microchim Acta 188, 124 (2021). https://doi.org/10.1007/s00604-021-04781-6
- Nitrogen-doped carbon tubes
- Cu-metal organic framework
- Molecular imprinted polymer