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Magnetic imprinted nanoparticles with synergistic tailoring of covalent and non-covalent interactions for purification and detection of procyanidin B2

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Abstract

A synergistic imprinting strategy of covalent and non-covalent interactions is proposed to prepare magnetic molecularly imprinted polymers (DI-MMIPs) for highly selective separation of procyanidin B2 (PC) from grape seed samples. Dopamine and 3-amino-phenylboronic acid as cooperative functional monomers endow the imprinted sites with synergistic tailoring. Benefiting from the synergistic effect, the DI-MMIPs exhibit enhanced imprinting performance with high adsorption capacity (27.71 mg g−1), fast kinetic equilibrium time (within 30 min), outstanding selectivity (IF = 5.8, SC > 3.2), and satisfactory regeneration ability. In addition, the DI-MMIPs possess good magnetism, uniform morphology with typical core-shell structure, and stable crystallization. Furthermore, the established DI-MMIPs coupled with HPLC-UV (~ 280 nm) method has a wide linearity range of 0.05–200 μg mL−1 with correlation coefficient of 0.9997, high recoveries (> 93.1%) with RSDs from 2.9 to 5.5%, and low LOD (0.0008 μg mL−1). Consequently, this work provides an effective and easily tailored way to fabricate magnetic imprinted nanomaterials with both rapid recognition rate and high selectivity and thus holds great promise to realize the extraction and detection of PC from real samples.

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Funding

This research received funding from the National Natural Science Foundation of China (Nos. 81701830, 31800286), the Natural Science Foundation of Shaanxi Province (2020JM-066, 2020JQ-019), the Fundamental Research Funds for the Central Universities (No. xjj2017028), and China Postdoctoral Science Foundation (Nos. 2016 M600800, 2017 M623200).

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  1. Haipin Zhang and Huijia Song contributed equally to this work and are co-first authors.

Authors and Affiliations

  1. School of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, 710061, Shaanxi, China

    Haipin Zhang, Yi Hao & Wenting Wang

  2. School of Chemistry, Xi’an Jiaotong University, Xi’an, 710049, Shaanxi, China

    Huijia Song, Xuemeng Tian, Yue Wang, Ruixia Gao & Yuhai Tang

  3. School of Medicine, Xi’an Jiaotong University, Xi’an, 710061, Shaanxi, China

    Wan Yang & YuShen Ke

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  1. Haipin Zhang
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Zhang, H., Song, H., Tian, X. et al. Magnetic imprinted nanoparticles with synergistic tailoring of covalent and non-covalent interactions for purification and detection of procyanidin B2. Microchim Acta 188, 17 (2021). https://doi.org/10.1007/s00604-020-04693-x

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