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Crystalline MOF nanofilm-based SALDI-MS array for determination of small molecules

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Abstract

A highly oriented crystalline metal-organic framework (MOF) nanofilm array was prepared and used for surface-assisted laser desorption ionization mass spectrometry (SALDI-MS) for determination of small molecules. The MOF nanofilm was characterized using scanning/transmission electron microscopy, X-ray diffraction, and ultraviolet-visible spectroscopy. Different small molecules (anthracene, n-eicosanoic acid, Rhodamine B) were successfully determined by this MOF nanofilm array with limits of detection (LOD) between 0.1–5 ng·mL−1 and limits of quantification (LOQ) between 1 and 10 ng·mL−1. Compared to previously reported MOF-based SALDI-MS, this array exhibits better reproducibility (3.3–5.2%) and recovery (89–105%). The intensity of the MS peak remains the same after 25 repeated cycles. This indicates good repeatability. This MOF nanofilm-based SALDI-MS array can be used for determination of fatty acid and Rhodamine B in real samples with good recovery (83–106%).

Schematic representation of the principle of crystalline MOFs nanofilm-based SALDI-MS array

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Funding

We acknowledge the financial support of the grants from the National Natural Science Foundation of China (21804003, 21904005).

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Authors and Affiliations

  1. School of Pharmacy, Bengbu Medical University, 2600 Donghai Avenue, Bengbu, 233030, China

    Yang Chen, Lu Zhang & Zijun Bie

  2. Department of Chemistry, Bengbu Medical University, 2600 Donghai Avenue, Bengbu, 233030, China

    Yang Chen, Ailan Huang & Zijun Bie

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  1. Yang Chen
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  2. Ailan Huang
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Correspondence to Zijun Bie.

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Chen, Y., Huang, A., Zhang, L. et al. Crystalline MOF nanofilm-based SALDI-MS array for determination of small molecules. Microchim Acta 187, 326 (2020). https://doi.org/10.1007/s00604-020-04310-x

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