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CuO/Cu composite nanospheres on a TiO2 nanotube array for amperometric sensing of glucose

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Abstract

A non-enzymatic glucose sensor based on the use of CuO-Cu nanospheres placed on a TiO2 nanotube (TNT) array with excellent performance is described. The electrode was fabricated by coating the CuO-Cu nanospheres onto the TNT array through electrochemical deposition. The CuO-Cu nanospheres with a diameter of ~200 nm are well dispersed on the TNT surface, which warrants smooth interaction and a 3D nanostructure with high uniformity. The modified electrode was then used for amperometric determination of glucose in 0.1 M NaOH solution. Figures of merit include (a) a typical working voltage of 0.65 V (vs. Ag/AgCl). (b) a linear range as wide as from 0.2–90 mM, (c) good sensitivity (234 μA mM−1 cm−2), and a 19 nM lower detection limit. The sensor is selective over ascorbic acid (AA), dopamine (DA), uric acid (UA), lactose, sucrose, and fructose.

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Acknowledgments

This work was supported by National Science Foundation (CBET-1805514) to HSZ.

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Authors and Affiliations

  1. Department of Chemical engineering, Worcester Polytechnic Institute, Worcester, MA, 01609, USA

    Zhiru Zhou, Zanzan Zhu, Feiyun Cui & Hong Susan Zhou

  2. National Cancer Centre Singapore, 31A Nanyang Ave. #07-02, Singapore, 639804, Singapore

    Zanzan Zhu

  3. School of Environmental Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China

    Jiahui Shao

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  1. Zhiru Zhou
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Zhou, Z., Zhu, Z., Cui, F. et al. CuO/Cu composite nanospheres on a TiO2 nanotube array for amperometric sensing of glucose. Microchim Acta 187, 123 (2020). https://doi.org/10.1007/s00604-019-4099-9

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