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Colorimetric determination of nine metal ions based on the de-aggregation of papain-functionalized gold nanoparticles and using three chelating agents

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Abstract

A colorimetric array for metal ions is described that is based on the de-aggregation of papain-capped gold nanoparticles (AuNPs) for discrimination of metal ions. The functionalized AuNPs were used as colorimetric probes, and three chelating agents (tripolyphosphate, citrate, and ethylenediamine tetraacetate were employed as the recognition receptors. In the absence of metal ions (Fe3+, Cr3+, Co2+, Mg2+, Pb2+, Ca2+, Zn2+, Ti4+, and Sn4+ were studied), the capped AuNPs are well dispersed in solution. In the presence of these ions, the metal ions bind papain and cause the AuNPs to aggregate. This causes a color change from red to purple. Different chelating agents induce different affinities between metal ions and papain. This results in distinct colorimetric response patterns. Linear discriminant analysis is used to discriminate the various metal ions on a three-dimensional spatial dispersion graph.

A colorimetric method is described for discrimination of metal ions. It is based on the chelation reaction between sensing receptors and metal ion-induced papain-functionalized AuNP deaggregation.

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Acknowledgements

This study was supported by Scientific Research Project of Beijing Educational Committee (Grant No. KM201710028009).

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Authors and Affiliations

  1. School of Biology and Food, Shangqiu Normal University, Wenhua Road No. 298, Shangqiu, 476000, People’s Republic of China

    Fangfang Jia

  2. College of Chemical and Environmental Engineering, Shandong University of Science and Technology, Qingdao, 266590, China

    Qingyun Liu

  3. Department of Chemistry, Capital Normal University, Beijing, 100048, China

    Zhengbo Chen

  4. School of Chemistry and Chemical Engineering, Shangqiu Normal University, Wenhua Road No. 298, Shangqiu, 476000, People’s Republic of China

    Wei Wei

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  1. Fangfang Jia
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  2. Qingyun Liu
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  3. Zhengbo Chen
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  4. Wei Wei
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Correspondence to Zhengbo Chen or Wei Wei.

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Jia, F., Liu, Q., Chen, Z. et al. Colorimetric determination of nine metal ions based on the de-aggregation of papain-functionalized gold nanoparticles and using three chelating agents. Microchim Acta 186, 854 (2019). https://doi.org/10.1007/s00604-019-4028-y

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  • DOI: https://doi.org/10.1007/s00604-019-4028-y

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