A flower-like hybrid material composed of Fe3O4, graphene oxide and CdSe nanodots for magnetic solid phase extraction of ibuprofen prior to its quantification by HPLC detection


A flower-like Fe3O4/GO/CdSe nanodot magnetic hybrid material was produced and applied to magnetic solid-phase extraction of ibuprofen from pharmaceuticals, water, and urine samples. The material was characterized by X-ray diffraction, Raman spectroscopy and field emission scanning electron microscopy and SEM-EDX. The pH value, volume of sample solution, amount of sorbent, type and volume of elution solvent and extraction time were optimized. Following elution with acetone, ibuprofen was quantified by HPLC-DAD detection. The recoveries of ibuprofen from spiked real samples ranged between 87 and 109%, and the intra-day and inter-day relative standard deviations from 1.25 to 3.02%. The limit of detection, limit of quantification and preconcentration factor are 0.36 ng·mL−1,1.20 ng·mL−1 and 150, respectively.

Schematic representation of the combination of flower-like Fe3O4/GO/CdSe nanodot-based magnetic solid phase extraction (MSPE) and high-performance liquid chromatography (HPLC) procedure for the extraction and analysis of ibuprofen in pharmaceuticals, water, and urine samples.

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This work has been supported by Erciyes University Scientific Research Projects Coordination Unit with research project FBA-2018-7761.

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Correspondence to Erkan Yilmaz.

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Sarp, G., Yilmaz, E. A flower-like hybrid material composed of Fe3O4, graphene oxide and CdSe nanodots for magnetic solid phase extraction of ibuprofen prior to its quantification by HPLC detection. Microchim Acta 186, 744 (2019). https://doi.org/10.1007/s00604-019-3875-x

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  • Hydrothermal synthesis
  • Non-steroidal anti-inflammatory drug
  • Pharmaceuticals
  • Urine samples
  • Water samples
  • Magnetic separation
  • Hummers method
  • Nanosorbent