A flower-like hybrid material composed of Fe3O4, graphene oxide and CdSe nanodots for magnetic solid phase extraction of ibuprofen prior to its quantification by HPLC detection

Microchimica Acta volume 186, Article number: 744 (2019) Cite this article

Abstract

A flower-like Fe3O4/GO/CdSe nanodot magnetic hybrid material was produced and applied to magnetic solid-phase extraction of ibuprofen from pharmaceuticals, water, and urine samples. The material was characterized by X-ray diffraction, Raman spectroscopy and field emission scanning electron microscopy and SEM-EDX. The pH value, volume of sample solution, amount of sorbent, type and volume of elution solvent and extraction time were optimized. Following elution with acetone, ibuprofen was quantified by HPLC-DAD detection. The recoveries of ibuprofen from spiked real samples ranged between 87 and 109%, and the intra-day and inter-day relative standard deviations from 1.25 to 3.02%. The limit of detection, limit of quantification and preconcentration factor are 0.36 ng·mL−1,1.20 ng·mL−1 and 150, respectively.

Schematic representation of the combination of flower-like Fe3O4/GO/CdSe nanodot-based magnetic solid phase extraction (MSPE) and high-performance liquid chromatography (HPLC) procedure for the extraction and analysis of ibuprofen in pharmaceuticals, water, and urine samples.

This is a preview of subscription content, log in to check access.

Access options

Buy single article

Instant access to the full article PDF.

US$ 39.95

Tax calculation will be finalised during checkout.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

References

  1. 1.

    Ghorbani M, Chamsaz M, Rounaghi GH (2016) Ultrasound-assisted magnetic dispersive solid-phase microextraction: A novel approach for the rapid and efficient microextraction of naproxen and ibuprofen employing experimental design with high performance liquid chromatography. J Sep Sci 39(6):1082–1089

    CAS  Article  Google Scholar 

  2. 2.

    Scheytt T, Mersmann P, Lindstädt R, Heberer T (2005) Determination of sorption coefficients of pharmaceutically active substances carbamazepine, diclofenac, and ibuprofen, in sandy sediments. Chemosphere 60(2):245–253

    CAS  Article  Google Scholar 

  3. 3.

    Wang Z, Srivastava V, Ambat I, Safaei Z, Sillanpää M (2019) Degradation of ibuprofen by UV-LED/catalytic advanced oxidation process. J Water Proc Eng 31:100808

    Article  Google Scholar 

  4. 4.

    Wolecki D, Caban M, Pazdro K, Mulkiewicz E, Stepnowski P, Kumirska J (2019) Simultaneous determination of non-steroidal anti-inflammatory drugs and natural estrogens in the mussels Mytilus edulis trossulus. Talanta 200:316–323

    CAS  Article  Google Scholar 

  5. 5.

    Ghani M, Ghoreishi SM, Salehinia S, Mousavi N, Ansarinejad H (2019) Electrochemically decorated network-like cobalt oxide nanosheets on nickel oxide nanoworms substrate as a sorbent for the thin film microextraction of diclofenac. Microchem J146:149–156

    Article  Google Scholar 

  6. 6.

    Wang T, Liu S, Gao G, Zhao P, Lu N, Lun X, Hou X (2017) Magnetic solid phase extraction of non-steroidal anti-inflammatory drugs from water samples using a metal organic framework of type Fe3O4/MIL-101 (Cr), and their quantitation by UPLC-MS/MS. Microchim Acta 184(8):2981–2990

    CAS  Article  Google Scholar 

  7. 7.

    Whelan MR, Ford JL, Powell MW (2002) Simultaneous determination of ibuprofen and hydroxypropylmethylcellulose (HPMC) using HPLC and evaporative light scattering detection. J Pharma Biomed 30(4):1355–1359

    CAS  Article  Google Scholar 

  8. 8.

    Vinci F, Fabbrocino S, Fiori M, Serpe L, Gallo P (2006) Determination of fourteen non-steroidal anti-inflammatory drugs in animal serum and plasma by liquid chromatography/mass spectrometry. Rapid Commun Mass Spectrom 20(22):3412–3420

    CAS  Article  Google Scholar 

  9. 9.

    Araujo L, Wild J, Villa N, Camargo N, Cubillan D, Prieto A (2008) Determination of anti-inflammatory drugs in water samples, by in situ derivatization, solid phase microextraction and gas chromatography–mass spectrometry. Talanta 75(1):111–115

    CAS  Article  Google Scholar 

  10. 10.

    Lpez-Bojrquez E, Castaeda-Hernndez G, Parra MGDL, Namur S (2008) Development and validation of a high-performance thin-layer chromatographic method, with densitometry, for quantitative analysis of ketorolac tromethamine in human plasma. J AOAC Int 91(5):1191–1195

    Article  Google Scholar 

  11. 11.

    Macià A, Borrull F, Calull M, Aguilar C (2007) Capillary electrophoresis for the analysis of non-steroidal anti-inflammatory drugs. TrAC Trend Anal Chem 26(2):133–153

    Article  Google Scholar 

  12. 12.

    Kormosh Z, Hunka I, Bazel Y, Matviychuk O (2010) Potentiometric determination of ketoprofen and piroxicam at a new PVC electrode based on ion associates of Rhodamine 6G. Mat Sci Eng C-Mater 30(7):997–1002

    CAS  Article  Google Scholar 

  13. 13.

    Shishov AY, Chislov MV, Nechaeva DV, Moskvin LN, Bulatov AV (2018) A new approach for microextraction of non-steroidal anti-inflammatory drugs from human urine samples based on in-situ deep eutectic mixture formation. J Mol Liq 272:738–745

    CAS  Article  Google Scholar 

  14. 14.

    Mafra G, Spudeit D, Brognoli R, Merib J, Carasek E (2018) Expanding the applicability of cork as extraction phase for disposable pipette extraction in multiresidue analysis of pharmaceuticals in urine samples. J Chromatogr B 1102:159–166

    Article  Google Scholar 

  15. 15.

    Li Y, Liao Y, Huang Y, Ye Z, Huang X (2019) Dual functional monomers modified magnetic adsorbent for the enrichment of non-steroidal anti-inflammatory drugs in water and urine samples. Talanta 201:496–502

    CAS  Article  Google Scholar 

  16. 16.

    Wang Y, Jia M, Wu X, Wang T, Wang J, Hou X (2019) PEG modified column MIL-101 (Cr)/PVA cryogel as a sorbent in stir bar solid phase extraction for determination of non-steroidal anti-inflammatory drugs in water samples. Microchem J 146:214–219

    CAS  Article  Google Scholar 

  17. 17.

    Khan M, Yilmaz E, Soylak M (2016) Vortex assisted magnetic solid phase extraction of lead (II) and cobalt (II) on silica coated magnetic multiwalled carbon nanotubes impregnated with 1-(2-pyridylazo)-2-naphthol. J Mol Liq 224:639–647

    CAS  Article  Google Scholar 

  18. 18.

    Hu B, He M, Chen B (2015) Nanometer-sized materials for solid-phase extraction of trace elements. Anal Bioanal Chem 407(10):2685–2710

    CAS  Article  Google Scholar 

  19. 19.

    Molaei R, Tajik H, Moradi M (2019) Magnetic solid phase extraction based on mesoporous silica-coated iron oxide nanoparticles for simultaneous determination of biogenic amines in an Iranian traditional dairy product; Kashk. Food Control 101:1–8

    CAS  Article  Google Scholar 

  20. 20.

    Yilmaz E, Ulusoy H. İ, Demir Ö, Soylak, M (2018). A new magnetic nanodiamond/graphene oxide hybrid (Fe3O4@ ND@ GO) material for pre-concentration and sensitive determination of sildenafil in alleged herbal aphrodisiacs by HPLC-DAD system. J Chromatogr B 1084:113–121

  21. 21.

    Herrero-Latorre C, Barciela-García J, García-Martín S, Peña-Crecente RM, Otárola-Jiménez J (2015) Magnetic solid-phase extraction using carbon nanotubes as sorbents: a review. Anal Chim Acta 892:10–26

    CAS  Article  Google Scholar 

  22. 22.

    Scida K, Stege PW, Haby G, Messina GA, García CD (2011) Recent applications of carbon-based nanomaterials in analytical chemistry: critical review. Anal Chim Acta 691(1–2):6–17

    CAS  Article  Google Scholar 

  23. 23.

    Liu Q, Shi J, Jiang G (2012) Application of graphene in analytical sample preparation. TrAC Trend Anal Chem 37:1–11

    Article  Google Scholar 

  24. 24.

    Yilmaz E, Soylak M (2017) Facile and green solvothermal synthesis of palladium nanoparticle-nanodiamond-graphene oxide material with improved bifunctional catalytic properties. J Iran Chem Soc 14(12):2503–2512

    CAS  Article  Google Scholar 

  25. 25.

    Ulusoy Hİ, Yılmaz E, Soylak M (2019) Magnetic solid phase extraction of trace paracetamol and caffeine in synthetic urine and wastewater samples by a using core shell hybrid material consisting of graphene oxide/multiwalled carbon nanotube/Fe3O4/SiO2. Microchem J 145:843–851

    CAS  Article  Google Scholar 

  26. 26.

    Zeinali S, Maleki M, Bagheri H (2019) Amine modified magnetic polystyrene for extraction of drugs from urine samples. J Chromatogr A 1602:107–116

    CAS  Article  Google Scholar 

  27. 27.

    Ali I, Kulsum U, Al-Othman ZA, Saleem K (2016) Analyses of nonsteroidal anti-inflammatory drugs in human plasma using dispersive nano solid-phase extraction and high-performance liquid chromatography. Chromatographia 79(3–4):145–157

    CAS  Article  Google Scholar 

  28. 28.

    Amiri A, Mirzaei M, Derakhshanrad S (2019) A nanohybrid composed of polyoxotungstate and graphene oxide for dispersive micro solid-phase extraction of non-steroidal anti-inflammatory drugs prior to their quantitation by HPLC. Microchim Acta 186(8):534

    Article  Google Scholar 

  29. 29.

    Seidi S, Sanàti SE (2019) Nickel-iron layered double hydroxide nanostructures for micro solid phase extraction of nonsteroidal anti-inflammatory drugs, followed by quantitation by HPLC-UV. Microchim Acta 186(5):297

    Article  Google Scholar 

  30. 30.

    Jian N, Qian L, Wang C, Li R, Xu Q, Li J (2019) Novel nanofibers mat as an efficient, fast and reusable adsorbent for solid phase extraction of non-steroidal anti-inflammatory drugs in environmental water. J Hazard Mater 363:81–89

    CAS  Article  Google Scholar 

  31. 31.

    Li W, Chen N, Zhu Y, Shou D, Zhi M, Zeng X (2019) A nanocomposite consisting of an amorphous seed and a molecularly imprinted covalent organic framework shell for extraction and HPLC determination of nonsteroidal anti-inflammatory drugs. Microchim Acta 186(2):76

    Article  Google Scholar 

Download references

Acknowledgments

This work has been supported by Erciyes University Scientific Research Projects Coordination Unit with research project FBA-2018-7761.

Author information

Affiliations

  1. Department of Analytical Chemistry, Faculty of Pharmacy, Erciyes University, 38050, Kayseri, Turkey

    Gokhan Sarp & Erkan Yilmaz

  2. ERNAM - Nanotechnology Research and Application Center, Erciyes University, 38039, Kayseri, Turkey

    Gokhan Sarp & Erkan Yilmaz

  3. Technology Research & Application Center (TAUM), Erciyes University, 38039, Kayseri, Turkey

    Erkan Yilmaz

Authors
  1. Gokhan Sarp
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Erkan Yilmaz
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Erkan Yilmaz.

Ethics declarations

Conflicts of interest

The author(s) declare that they have no competing interests.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

ESM 1

(DOCX 238 kb)

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Sarp, G., Yilmaz, E. A flower-like hybrid material composed of Fe3O4, graphene oxide and CdSe nanodots for magnetic solid phase extraction of ibuprofen prior to its quantification by HPLC detection. Microchim Acta 186, 744 (2019). https://doi.org/10.1007/s00604-019-3875-x

Download citation

Keywords

  • Hydrothermal synthesis
  • Non-steroidal anti-inflammatory drug
  • Pharmaceuticals
  • Urine samples
  • Water samples
  • Magnetic separation
  • Hummers method
  • Nanosorbent