Cobalt-doped nanoporous carbon as SALDI-TOF-MS adsorbent and matrix for quantification of cetyltrimethylammonium bromide, Rhodamine B and Malachite Green at sub-ppt levels

Abstract

Cobalt-doped nanoporous carbon (Co-NPC) with dodecahedral shape was pyrolytically synthesized and applied as a sorbent and matrix for the enrichment and analysis of small molecules by surface-assisted laser desorption/ionization time-of-flight mass spectrometry (SALDI-TOF MS). Extremely low detection limits were accomplished for cetyltrimethylammonium bromide (1 fg·mL−1), and Rhodamine B (1 fg·mL−1) in water, and Malachite Green and its metabolite in fish blood and fish extracts (pg·mL−1 concentrations).

Schematic representation of cobalt-doped nanoporous carbons (Co-NPCs) applied as SALDI matrix for analysis of toxic contaminants in fish and receipt papers. The Co-NPCs have a high desorption/ionization efficiency and low limit of detection.

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Acknowledgements

This work was supported by a grant from National Natural Science Foundation of China (21874038).

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Correspondence to Qingyun Cai.

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Zhen, D., Jiang, N., Geng, H. et al. Cobalt-doped nanoporous carbon as SALDI-TOF-MS adsorbent and matrix for quantification of cetyltrimethylammonium bromide, Rhodamine B and Malachite Green at sub-ppt levels. Microchim Acta 186, 691 (2019). https://doi.org/10.1007/s00604-019-3816-8

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Keywords

  • Cobalt nanoparticles
  • Carbon dodecahedrons
  • Receipt papers
  • Carassius auratus
  • Toxic contaminants
  • Mass spectrometry