Cobalt-doped nanoporous carbon (Co-NPC) with dodecahedral shape was pyrolytically synthesized and applied as a sorbent and matrix for the enrichment and analysis of small molecules by surface-assisted laser desorption/ionization time-of-flight mass spectrometry (SALDI-TOF MS). Extremely low detection limits were accomplished for cetyltrimethylammonium bromide (1 fg·mL−1), and Rhodamine B (1 fg·mL−1) in water, and Malachite Green and its metabolite in fish blood and fish extracts (pg·mL−1 concentrations).
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Yang YH, Chan AL, Lavallo V, Cheng Q (2016) Quantitation of alpha-glucosidase activity using fluorinated carbohydrate Array and MALDI-TOF-MS. ACS Appl Mater Interfaces 8:2872–2878
Shi C, Meng J, Deng C (2012) Enrichment and detection of small molecules using magnetic graphene as an adsorbent and a novel matrix of MALDI-TOF-MS. Chem Commun 48:2418–2420
Zhen D, Gao C, Zhu B, Zhou Q, Li C, Chen P, Cai Q (2018) Preparation of Bi0.15Fe0.15TiO2 nanocomposites for the highly selective enrichment of Phosphopeptides. Anal Chem 90:12414–12421
Liu R, Liu J, Zhou X, Jiang G (2011) Cysteine modified small ligament au Nanoporous film: An easy fabricating and highly efficient surface-assisted laser desorption/ionization substrate. Anal Chem 83:3668–3674
Li Z, Zhang Y, Xin Y, Bai Y, Zhou H, Liu H (2014) A lithium-rich composite metal oxide used as a SALDI-MS matrix for the determination of small biomolecules. Chem Commun 50:15397–15399
Lu W, Li R, Shuang S, Dong C, Cai Z (2016) Facile synthesis of N-doped carbon dots as a new matrix for detection of Hydroxy-polycyclic aromatic hydrocarbons by negative-ion matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. ACS Appl Mater Interfaces 8:12976–12984
Liu Q, Cheng M, Wang J, Jiang G (2015) Graphene oxide nanoribbons: improved synthesis and application in MALDI mass spectrometry. Chem 21:5594–5599
Zhou XZ, Wei YY, He QY, Boey F, Zhang QC, Zhang H (2010) Reduced graphene oxide films used as matrix of MALDI-TOF-MS for detection of octachlorodibenzo-p-dioxin. Chem Commun 46:6974–6976
Nouri N, Khorram P, Sereshti H (2019) Applications of three-dimensional graphenes for preconcentration, extraction, and sorption of chemical species: a review. Microchim Acta 186:232–246
Huang X, Liu Q, Huang XY, Nie Z, Ruan T, Du YG, Jiang GB (2017) Fluorographene as a mass spectrometry probe for high-throughput identification and screening of emerging chemical contaminants in complex samples. Anal Chem 89:1307–1314
Finkel NH, Prevo BG, Velev OD, He L (2005) Ordered silicon nanocavity arrays in surface-assisted desorption/ionization mass spectrometry. Anal Chem 77:1088–1095
Huang YF, Chang HT (2006) Nile red-adsorbed gold nanoparticle matrixes for determining aminothiols through surface-assisted laser desorption/ionization mass spectrometry. Anal Chem 78:1485–1493
Chiu TC, Chang LC, Chiang CK, Chang HT (2008) Determining estrogens using surface-assisted laser desorption/ionization mass spectrometry with silver nanoparticles as the matrix. J Am Soc Mass Spectrom 19:1343–1346
Gao C, Zhen D, He N, An Z, Zhou Q, Li C, Grimes CA, Cai Q (2019) Two-dimensional TiO2 nanoflakes enable rapid SALDI-TOF-MS detection of toxic small molecules (dyes and their metabolites) in complex environments. Talanta 196:1–8
Watanabe T, Kawasaki H, Yonezawa T, Arakawa R (2010) Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) of low molecular weight organic compounds and synthetic polymers using zinc oxide (ZnO) nanoparticles. J Mass Spectrom 43:1063–1071
McAlpin CR, Voorhees KJ, Corpuz AR, Richards RM (2012) Analysis of lipids: metal oxide laser ionization mass spectrometry. Anal Chem 84:7677–7683
Kailasa SK, Wu HF (2013) Surface-assisted laser desorption-ionization mass spectrometry of;oligosaccharides using magnesium oxide nanoparticles as a matrix. Microchim Acta 180:405–413
Wang S, Niu H, Zeng T, Zhang X, Cao D, Cai Y (2017) Rapid determination of small molecule pollutants using metal-organic frameworks as adsorbent and matrix of MALDI-TOF-MS. Microporous Mesoporous Mat 239:390–395
Liu HL, Chang YJ, Fan T, Gu ZY (2016) Two-dimensional metal-organic framework nanosheets as a matrix for laser desorption/ionization of small molecules and monitoring enzymatic reactions at high salt concentrations. Chem Commun 52:12984–12987
Min Q, Zhang X, Chen X, Li S, Zhu JJ (2014) N-doped graphene: An alternative carbon-based matrix for highly efficient detection of small molecules by negative ion MALDI-TOF MS. Anal Chem 86:9122–9130
Nazari S, Mehri A, Hassannia AS (2017) Fe3O4-modified graphene oxide as a sorbent for sequential magnetic solid phase extraction and dispersive liquid phase microextraction of thallium. Microchim Acta 184:3239–3246
Tanaka K, Waki H, Ido Y, Akita S, Yoshida T (1988) Protein and polymer analyses up to m/z 100 000 by laser ionization time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 2:151–153
Li Y, Liu J, Chen C, Zhang X, Chen J (2017) Preparation of NiCoP hollow quasi-Polyhedra and their Electrocatalytic properties for hydrogen evolution in alkaline solution. ACS Appl Mater Interfaces 9:5982–5991
Meng J, Niu C, Xu L, Li J, Liu X, Wang X, Wu Y, Xu X, Chen W, Li Q, Zhu Z, Zhao D, Mai L (2017) General oriented formation of carbon nanotubes from metal-organic frameworks. J Am Chem Soc 139:8212–8221
Mahmood A, Guo WH, Tabassum H, Zou RQ (2016) Metal-organic framework-based nanomaterials for Electrocatalysis. Adv Energy Mater 6:1600423–1600450
Zhang X, Jiang W, Song D, Liu Y, Geng J, Li F (2009) Preparation and catalytic activity of Co/CNTs nanocomposites via microwave irradiation. Propell Explos Pyrot 34:151–154
Lin Z, Zheng J, Lin G, Tang Z, Yang X, Cai Z (2015) Negative ion laser desorption/ionization time-of-flight mass spectrometric analysis of small molecules using graphitic carbon nitride Nanosheet matrix. Anal Chem 87:8005–8012
Wang J, Liu Q, Gao Y, Wang Y, Guo L, Jiang G (2015) High-throughput and rapid screening of low-mass hazardous compounds in complex samples. Anal Chem 87:6931–6936
Yalcin T, Wallace WE, Guttman CM, Liang L (2002) Metal powder substrate-assisted laser desorption/ionization mass spectrometry for polyethylene analysis. Anal Chem 74:4750–4756
Wang J, Liu Q, Gao Y, Wang YW, Guo LQ, Jiang GB (2015) High-throughput and rapid screening of low-mass hazardous compounds in complex samples. Anal Chem 87:6931–6936
Gulbakan B, Yasun E, Shukoor MI, Zhu Z, You M, Tan X, Sanchez H, Powell DH, Dai H, Tan W (2010) A dual platform for selective analyte enrichment and ionization in mass spectrometry using aptamer-conjugated graphene oxide. J Am Chem Soc 132:17408–17410
Inplemeting Council Dirextive 96/23/EC concerning the performance of analytical methods and the interpretation of results, Offical Journal of the European Communities. Brussels. Belgium (2002) 8–36
Kim YK, Na HK, Kwack SJ, Ryoo SR, Lee Y, Hong S, Hong S, Heong Y, Min DH (2011) Synergistic effect of graphene oxide/MWCNT films in laser desorption/ionization mass spectrometry of small molecules and tissue imaging. ACS Nano 5:4550–4561
Qiu S, Zhao F, Zenasni Q, Li J, Shih WC (2016) Nanoporous gold disks functionalized with stabilized G-Quadruplex moieties for sensing small molecules. ACS Appl Mater Interfaces 8:29968–29976
Im K, Nguyen D, Kim S, Kong HJ, Kim Y, Park CS, Kwon OS, Yoon H (2017) Graphene-embedded hydrogel nanofibers for detection and removal of aqueous-phase dyes. ACS Appl Mater Interfaces 9:10768–10776
This work was supported by a grant from National Natural Science Foundation of China (21874038).
Conflict of interest
The authors declare no competing financial interest.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Electronic supplementary material
About this article
Cite this article
Zhen, D., Jiang, N., Geng, H. et al. Cobalt-doped nanoporous carbon as SALDI-TOF-MS adsorbent and matrix for quantification of cetyltrimethylammonium bromide, Rhodamine B and Malachite Green at sub-ppt levels. Microchim Acta 186, 691 (2019). https://doi.org/10.1007/s00604-019-3816-8
- Cobalt nanoparticles
- Carbon dodecahedrons
- Receipt papers
- Carassius auratus
- Toxic contaminants
- Mass spectrometry