Abstract
Fluorescence resonance energy transfer, one of the most powerful phenomena for elucidating molecular interactions, has been extensively utilized as a biosensing tool to provide accurate information at the nanoscale. Numerous aptamer- and nanomaterial-based FRET bioassays has been developed for detection of a large variety of molecules. Affinity probes are widely used in biosensors, in which aptamers have emerged as advantageous biorecognition elements, due to their chemical and structural stability. Similarly, optically active nanomaterials offer significant advantages over conventional organic dyes, such as superior photophysical properties, large surface-to-volume ratios, photostability, and longer shelf life. In this report (with 175 references), the use of aptamer-modified nanomaterials as FRET couples is reviewed: quantum dots, upconverting nanoparticles, graphene, reduced graphene oxide, gold nanoparticles, molybdenum disulfide, graphene quantum dots, carbon dots, and metal-organic frameworks. Tabulated summaries provide the reader with useful information on the current state of research in the field.
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Abbreviations
- AD:
-
Adenosine
- AFP:
-
Alphafeto protein
- AuNPs:
-
Gold nanoparticles
- AuNRs:
-
Gold nanorods
- AuNCs:
-
Gold nanoclusters
- BHQ1:
-
Black Hole Quencher 1
- BHQ2:
-
Black Hole Quencher 2
- cDNA:
-
Complementary DNA
- CDs:
-
Carbon Dots
- CEA:
-
Carcinoembryonic antigen
- CTC:
-
Circulating tumor cells
- EpCAM:
-
Epithelial cell adhesion molecule
- FAM:
-
5′-carboxyfluorescein
- FRET:
-
Förster resonance energy transfer
- GA:
-
Glycated albumin
- GO:
-
Graphene oxide
- GQDs:
-
Graphene quantum dots
- LRET:
-
Luminescence resonance energy transfer
- LSPR:
-
Localized surface plasmon resonance
- MFNs:
-
Magnetic fluorescent nanocomposite
- MNPs:
-
Metal nanoparticles
- MOFs:
-
Metal-organic frameworks
- MoS2:
-
Molybdenum disulfide
- NIR:
-
Near-infrared Region
- NSET:
-
Nanosurface resonance energy transfer
- OTA:
-
Ochratoxin
- QD:
-
Quantum dot
- RB:
-
Rhodamine B
- rGO:
-
Reduced Graphene Oxide
- rQD:
-
Red-emitting QDs
- gQDs:
-
Green-emitting QDs
- SELEX:
-
Systematic evolution of ligands by exponential enrichment
- ssDNA:
-
Single-stranded DNA
- TMD-NSs:
-
Transition metal dichalcogenides nanosheets
- UCNP:
-
Upconverting nanoparticles
- UV:
-
Ultraviolet
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Pehlivan, Z.S., Torabfam, M., Kurt, H. et al. Aptamer and nanomaterial based FRET biosensors: a review on recent advances (2014–2019). Microchim Acta 186, 563 (2019). https://doi.org/10.1007/s00604-019-3659-3
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DOI: https://doi.org/10.1007/s00604-019-3659-3