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Determination and removal of clenbuterol with a stable fluorescent zirconium(IV)-based metal organic framework

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Abstract

A metal organic framework (MOF) based adsorbent of type UiO-66 was hydrothermally prepared and applied to simultaneous sensing and removal of the asthma drug clenbuterol. The MOF possesses a large specific surface area (1460 cm2·g−1) and a stable structure, and has a large adsorption capacity for clenbuterol (160 mg·g−1). If clenbuterol binds to the MOF, the fluorescence of the sorbent (best measured at excitation/emission wavelengths of 290/396 nm) is quenched by up to 88%. Based on these findings, a fluorometric assay has been developed for the rapid determination of clenbuterol. The adsorption equilibrium of UiO-66 for CLB can be achieved at 60 min and the adsorption efficiency is above 80%. The method has a linear response in the 4.0 to 40 ng·mL−1 concentration range, and the lower limit of detection is 0.17 μM. All of this indicates that UiO-66 is promising for simultaneous detection and the removal of CLB in water.

Schematic presentation of the detection and removal of clenbuterol in water medium by a stable fluorescent Zr(IV)-based metal organic framework. This method exhibited a large adsorption capacity for clenbuterol (160 mg/g) and low limit of detection (0.17 μM)

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Acknowledgements

The authors would like to thank the China National Key R&D Program (2017YFC1601604), NSFC (No.21777189) and China Central Basic Research Program (Y2018PT23) for financially supporting this research.

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Authors and Affiliations

  1. Institute of Quality Standards and Testing Technology for Agro-products, Chinese Academy of Agricultural Sciences, Beijing, 100081, People’s Republic of China

    Haosen Yang, Jie Cheng, Ruiguo Wang, Su Zhang, Shujun Dong, Shulin Wei & Peilong Wang

  2. Beijing Key Laboratory for Green Catalysis and Separation and Department of Chemistry and Chemical Engineering, College of Environ-mental and Energy Engineering, Beijing University of Technology, Beijing, 100124, People’s Republic of China

    Bin Wang & Jian-Rong Li

  3. College of Chemistry and Chemical Engineering, Fujian Provincial Key Laboratory of Polymer Materials, Fujian Normal University, Fuzhou, 350007, People’s Republic of China

    Bin Wang

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  1. Haosen Yang
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Correspondence to Peilong Wang.

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Yang, H., Wang, B., Cheng, J. et al. Determination and removal of clenbuterol with a stable fluorescent zirconium(IV)-based metal organic framework. Microchim Acta 186, 454 (2019). https://doi.org/10.1007/s00604-019-3586-3

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