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Polydopamine-assisted immobilization of a zinc(II)-derived metal-organic cage as a stationary phase for open-tubular capillary electrochromatography

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Abstract

A capillary column was modified with a soluble zinc(II)-derived metal-organic cage (MOC) [Zn2L] as the stationary phase to obtain a new coating layer for use in open-tubular capillary electrochromatography. The inner surface of the capillary was first coated with a layer of polydopamine. Then, a solution of the MOC in dichloromethane was introduced into the capillary upon which it is bonded both covalently and non-covalently. The resulting coating layer on the capillary was characterized by scanning electron microscopy and Fourier transform infrared spectroscopy. The results demonstrated the successful formation of the [Zn2L] modified open-tubular column. The column showed good separation performance towards neutral compounds (such as methylbenzene, ethylbenzene, n-propylbenzene and n-butylbenzene), acidic drugs (such as ibuprofen, ketoprofen, flurbiprofen and diclofenac sodium), food additives (such as parabens, vanillin and related phenolic compounds) and small biomolecules (such as nucleosides and nucleotide bases) by π-interaction and hydrophobic interaction. It also exhibited good precision, the relative standard deviations of the retention time for intra-day, inter-day runs and column-to-column being <1.6%, 2.8%, and 4.0%, respectively.

Schematic presentation of the open-tubular column modified with zinc(II)-derived metal-organic cage by polydopamine-assisted strategy onto the inner wall of capillary for electrochromatographic separations.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Grant Nos. 81872828 and 81573384).

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Authors and Affiliations

  1. Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China

    Zhentao Li, Zhenkun Mao & Zilin Chen

  2. State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Beijing, 10080, China

    Zhentao Li, Zhenkun Mao & Zilin Chen

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  1. Zhentao Li
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  2. Zhenkun Mao
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  3. Zilin Chen
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Correspondence to Zilin Chen.

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Li, Z., Mao, Z. & Chen, Z. Polydopamine-assisted immobilization of a zinc(II)-derived metal-organic cage as a stationary phase for open-tubular capillary electrochromatography. Microchim Acta 186, 449 (2019). https://doi.org/10.1007/s00604-019-3576-5

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