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A chitosan grafted mesoporous carbon aerogel for ultra-sensitive voltammetric determination of isoniazid

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Abstract

A screen-printed carbon electrode (SPCE) was modified with chitosan (Chit) supported on carbon aerogel (CA) to obtain an electrochemical sensor for the tuberculosis drug isoniazid (INZ). The interconnected mesoporous structure of Chit/CA provides a large surface area (SBET = 461 m2 g−1) and good porosity (VTot = 0.69 cm3 g−1). Besides, the modified SPCE displayed enhanced electrocatalytic activity due to the presence of numerous active sites (such as >C=O, -NH-, -NH2, -OH). Figures of merit include (a) a typical working voltage of 0.28 V (vs. Ag/AgCl), (b) high sensitivity (8.09 μA μM−1 cm−2), (c) a wide linear response to INZ (0.01–115 μM) and (d) a low detection limit (8 nM). The modified electrode has successfully been applied to the determination of INZ in spiked serum and urine, and recoveries ranged from 97.8 to 99.8%.

Schematic illustration of preparation and applications of a nanocomposite consisting of chitosan (Chit; CS) supported on carbon aerogel (CA) for electrochemical detection of isoniazid.

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Acknowledgments

R.S. acknowledge the support provided by the Academia Sinica research program on Nanoscience and Nanotechnology under project number NM004. RS acknowledges the support by the Development of Novel Thermoelectric Materials for Sustainable Energy Academia Sinica in Taiwan AS-SS-106-01-1. The authors are grateful for the financial support (MOST106-2113-M-027-003 and MOST106-2221-E-182-021) from the Ministry of Science and Technology (MOST), Taiwan.

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Author notes

  1. Chellakannu Rajkumar and Raja Nehru contributed equally to this work.

Authors and Affiliations

  1. Institute of Physics, Academia Sinica, Taipei, 10617, Taiwan

    Chellakannu Rajkumar, Raja Nehru & Raman Sankar

  2. Centre for Condensed Matter Sciences, National Taiwan University, Taipei, 10617, Taiwan

    Chellakannu Rajkumar & Raman Sankar

  3. Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, 10608, Taiwan

    Raja Nehru, Shen-Ming Chen &  Qin-JinYeah

  4. Center for High Pressure Research, Bharathidasan University, Tiruchirappalli, 620 024, India

    S. Arumugam

Authors
  1. Chellakannu Rajkumar
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  2. Raja Nehru
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  3. Shen-Ming Chen
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  4. S. Arumugam
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  5. Qin-JinYeah
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Correspondence to Shen-Ming Chen or Raman Sankar.

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Rajkumar, C., Nehru, R., Chen, SM. et al. A chitosan grafted mesoporous carbon aerogel for ultra-sensitive voltammetric determination of isoniazid. Microchim Acta 186, 419 (2019). https://doi.org/10.1007/s00604-019-3533-3

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