Abstract
Two dimensional single-crystal hexagonal gold nanosheets (SCHGNSs) were prepared by microwave heating of a solution of HAuCl4 in an ionic liquid. The SCHGNSs were characterized by field emission electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, atomic force microscopy and electrochemical impedance spectroscopy. The SCHGNSs were then used to modify a graphite paste electrode for voltammetric determination of the hypertension drug captopril (CAP). The modified electrode showed a well-defined oxidation peak (at 0.41 V vs. Ag/AgCl) at pH 7.0 using differential pulse voltammetry. Under the optimum conditions, the response is linear in the 2–400 nM and 4.0–50 μM CAP concentration range, and the detection limit (at S/N = 3) is 0.3 nM. The sensor was successfully applied to the determination of CAP in pharmaceutical tablets and in spiked urine.
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Shahbakhsh, M., Noroozifar, M. 2D-Single-crystal hexagonal gold nanosheets for ultra-trace voltammetric determination of captopril. Microchim Acta 186, 195 (2019). https://doi.org/10.1007/s00604-019-3260-9
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DOI: https://doi.org/10.1007/s00604-019-3260-9