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A Zr(IV)-based porphyrinic metal-organic framework as a solid-phase sorbent for extraction of sulfonamides prior to their quantitation by LC-MS

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Abstract

A porphyrinic metal–organic framework (PCN-224) was fabricated and used as an adsorbent for solid-phase extraction of ultratrace levels of polar sulfonamide antibiotics from food and drinking waters. The PCN-224 was characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, and powder X-ray diffraction analyses. Parameters affecting the extraction efficiency were optimized. The sulfonamides were quantified by liquid chromatography-tandem mass spectrometry. Figures of merit include (a) low limits of detection (0.07–0.47 ng·L−1), (b) wide linear ranges (0.5–2000 ng·L−1), and (c) good repeatabilities (2.8%–6.7%) and reproducibilities (1.7%–5.1%). The method was successfully applied to the determination of sulfonamides in food and drinking water samples.

A Zr(IV)-based porphyrinic metal−organic framework (PCN-224) was synthesized from a Zr6 cluster and the H2TCPP ligand. It was used for solid-phase extraction of sulfonamides from food and drinking water samples coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS) for determination.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (21777089 and 21477068), the Natural Science Foundation of Shandong Province (ZR2018MB040), the Key Research and Development Program of Shandong Province (2017GSF17107 and 2018GSF117036), and Shandong Province Taishan Scholar Program (ts201712063).

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Authors and Affiliations

  1. Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250014, China

    Ze-Hui Deng, Gui-Ju Xu, Xiao-Li Wang, Xia Wang & Ru-Song Zhao

  2. College of Food Science and Engineering, Shandong Agricultural University, Taian, 271018, China

    Ze-Hui Deng & Ming-Lin Wang

  3. Department of Chemistry, Tsinghua University, Beijing, 100084, China

    Jin-Ming Lin

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  1. Ze-Hui Deng
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  2. Gui-Ju Xu
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  4. Xia Wang
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  6. Jin-Ming Lin
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  7. Ru-Song Zhao
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Correspondence to Ru-Song Zhao.

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Deng, ZH., Xu, GJ., Wang, XL. et al. A Zr(IV)-based porphyrinic metal-organic framework as a solid-phase sorbent for extraction of sulfonamides prior to their quantitation by LC-MS. Microchim Acta 185, 450 (2018). https://doi.org/10.1007/s00604-018-2985-1

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