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Synthesis of tellurium nanosheet for use in matrix assisted laser desorption/ionization time-of-flight mass spectrometry of small molecules

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Abstract

Two-dimensional tellurium nanosheets were prepared by a hydrothermal method and characterized by scanning electron microscopy, powder X-ray diffractometry, and UV-vis spectroscopy. The nanosheets were explored as a novel matrix for desorption/ionization of small molecules including nucleobases, fatty acids and amino acids by matrix assisted laser desorption/ionization time-of-flight mass spectrometry. The results show that the tellurium nanosheets have good UV light absorption, cause low matrix ion interference in the low-molecule-mass region, and have high desorption/ionization efficiency in the negative ion mode. Hence, they are a viable matrix for negative ion desorption/ionization in MALDI-TOF MS of small molecules. In order to investigate the desorption/ionization mechanisms, benzylpyridinium salt and bisphenol A were adopted as probes. The results show that both of the electronic transitions mechanism and laser-induced thermal mechanism play important roles in desorption/ionization process.

Two-dimensional tellurium (Te) nanosheet was synthesized by a hydrothermal method and explored as a novel matrix for desorption/ionization of small molecules by matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS).

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Acknowledgments

This work was funded by the National Key R&D Program of China (2017YFC0906800), National Natural Science Foundation of China (21635006, 21475098, 31670373, 21605117).

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Authors and Affiliations

  1. Department of Chemistry, Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Wuhan University, Wuhan, 430072, People’s Republic of China

    Ya-Shun Chen, Jun Ding, Xiao-Mei He, Jing Xu & Yu-Qi Feng

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Correspondence to Yu-Qi Feng.

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Chen, YS., Ding, J., He, XM. et al. Synthesis of tellurium nanosheet for use in matrix assisted laser desorption/ionization time-of-flight mass spectrometry of small molecules. Microchim Acta 185, 368 (2018). https://doi.org/10.1007/s00604-018-2882-7

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