Microchimica Acta

, 185:313 | Cite as

Synthesis and characterization of manganese diselenide nanoparticles (MnSeNPs): Determination of capsaicin by using MnSeNP-modified glassy carbon electrode

  • Ramaraj Sukanya
  • Mani Sakthivel
  • Shen-Ming Chen
  • Tse-Wei Chen
  • Fahad M. A. Al-Hemaid
  • M. Ajmal Ali
  • Mohamed Soliman Elshikh
Original Paper


A new type of manganese diselenide nanoparticles (MnSeNPs) was synthesized by using a hydrothermal method. Their surface morphology, crystallinity and elemental distribution were characterized by using transmission electron microscopy, X-ray diffraction, energy dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy which scrutinize the formation of the NPs. The NPs were coated on a glassy carbon electrode (GCE), and electrochemical impedance spectroscopy, cyclic voltammetry and differential pulse voltammetry were applied to study the electroanalytical properties towards the oxidation of the food additive capsaicin. The modified GCE displays lower charge transfer resistance (R ct  = 29.52 Ω), a larger active surface area (0.089 cm2/g, and more efficient electrochemical oxidation of capsaicin compared to a MnS2/GCE and a bare GCE. The oxidation peak potential is 0.43 V (vs. Ag/AgCl) which is lower than that of previously reported GCEs. The sensor has a detection limit as low as 0.05 μM and an electrochemical sensitivity of 2.41 μA μM−1 cm−2. The method was applied to the determination of capsaicin in pepper samples.

Graphical abstract

Electrochemical determination of capsaicin in pepper extract by using MnSeNPs modified electrode.


Manganese diselenide Hydrothermal synthesis Electrochemical sensor Capsaicin Metal chalcogenides Pepper sample Capsaicinoid 



The authors extend their appreciation to the International Scientific Partnership Program ISPP at King Saud University for funding this research work through ISPP# 124.The authors gratefully acknowledge the financial support of the Ministry of Science and Technology, Taiwan through contract Nos: MOST106-2113-M-027-004 and MOST106-2221-E-182-021.

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2018_2851_MOESM1_ESM.docx (1.6 mb)
ESM 1 (DOCX 1676 kb)


  1. 1.
    Patil AM, Lokhande VC, Patil UM, Shinde PA, Lokhande CD (2018) High performance all-solid-state asymmetric supercapacitor device based on 3D Nanospheres of β-MnO2 and Nanoflowers of O-SnS. ACS Sustain Chem Eng 6:787–802CrossRefGoogle Scholar
  2. 2.
    Cheng C, Kong D, Wei C, Du W, Zhao J, Feng Y, Duan Q (2017) Self-template synthesis of hollow ellipsoid Ni–Mn sulfides for supercapacitors, electrocatalytic oxidation of glucose and water treatment. Dalton Trans 46:5406–5413CrossRefPubMedGoogle Scholar
  3. 3.
    Yi X, He W, Zhang X, Yang G, Wang Y (2018) Hollow mesoporous MnO/MnS/SiC/S-CN composites prepared from soda pulping black liquor for lithium-ion batteries. J Alloys Compd 735:1306–1313CrossRefGoogle Scholar
  4. 4.
    Jiang B, Muddemann T, Kunz U, Bormann H, Niedermeiser M, Haupt D, Schl¨afer O, Sievers M (2017) Evaluation of microbial fuel cells with graphite plus MnO2 and MoS2 paints as oxygen reduction cathode catalyst. J Electrochem Soc 164(3):3083–3090CrossRefGoogle Scholar
  5. 5.
    Kishore B, Nookala M (2017) Electrochemical impedance studies of Na/MnO2 primary cells. J Electroanal Chem 799:134–141CrossRefGoogle Scholar
  6. 6.
    Xiong X, Ji Y, Xie M, You C, Yang L, Liu Z, Asiri AM, Sun X (2018) MnO2-CoP3 nanowires array: an efficient electrocatalyst for alkaline oxygen evolution reaction with enhanced activity. Electrochem Commun 86:161–165CrossRefGoogle Scholar
  7. 7.
    Sakthivel M, Ramaraj S, Chen SM, Dinesh B, Ramasamy HV, Lee YS (2018) Entrapment of bimetallic CoFeSe2 nanosphere on functionalized carbon nanofiber for selective and sensitive electrochemical detection of caffeic acid in wine samples. Anal Chim Acta 1006:22–32CrossRefPubMedGoogle Scholar
  8. 8.
    Mi L, Sun H, Ding Q, Chen W, Liu C, Hou H, Zheng Z, Shen C (2012) 3D hierarchically patterned tubular NiSe with nano−/microstructures for Li ion battery design. Dalton Trans 41:12595–12600CrossRefPubMedGoogle Scholar
  9. 9.
    Wang W, Dong Y, Xu L, Dong W, Niu X, Lei Z (2017) Combining bimetallic-alloy with selenium functionalized carbon to enhance Electrocatalytic activity towards glucose oxidation. Electrochim Acta 244:16–25CrossRefGoogle Scholar
  10. 10.
    Stoerzinger KA, Risch M, Han B, Horn YS (2015) Recent insights into manganese oxides in catalyzing oxygen reduction kinetics. ACS Catal 5:6021–6031CrossRefGoogle Scholar
  11. 11.
    Balamuralitharan B, Karthick SN, Balasingam SK, Hemalatha KV, Selvam S, Anandha Raj J, Prabakar K, Jun Y, Kim HJ (2017) Hybrid reduced graphene oxide/MnSe2 cubes: a new electrode material for supercapacitors. Energ Technol 5:1953–1962. CrossRefGoogle Scholar
  12. 12.
    Li X, Shen J, Li N, Ye M (2015) Fabrication of g-MnS/rGO composite by facile one-pot solvothermal approach for supercapacitor applications. J Power Sources 282:194–201CrossRefGoogle Scholar
  13. 13.
    Tang Q, Jiang L, Liu J, Wang S, Sun G (2014) Effect of surface manganese valence of manganese oxides on the activity of the oxygen reduction reaction in alkaline media. ACS CATAL 4:457–463CrossRefGoogle Scholar
  14. 14.
    Raj S, Padhi HC, Polasik M (2000) Infuence of chemical effect on the Kβ-to-Kα x-ray intensity ratios of Cr, Mn and co in CrSe, MnSe, MnS and CoS. Nucl Instrum Methods Phys Res, Sect B 160:443–448CrossRefGoogle Scholar
  15. 15.
    Mohammad R, Ahmad M, Heng LY (2017) Amperometric capsaicin biosensor based on covalent immobilization of horseradish peroxidase (HRP) on acrylic microspheres for chilli hotness determination. Sensors Actuators B Chem 241:174–181CrossRefGoogle Scholar
  16. 16.
    Shamsi S, Tran H, Tan RSJ, Tan ZJ, Lim LY (2017) Curcumin, Piperine, and capsaicin: a comparative study of spice-mediated inhibition of human cytochrome P450 isozyme activities. Drug Metab Dispos 45:49–55CrossRefPubMedGoogle Scholar
  17. 17.
    Friedman JR, Perry HE, Brown KC, Gao Y, Lin J, Stevenson CD, Hurley JD, Nolan NA, Akers AT, Chen YC, Denning KL, Brown LG, Dasgupta P (2017) Capsaicin synergizes with camptothecin to induce increased apoptosis in human small cell lung cancers via the calpain pathway. Biochem Pharmacol 129:54–66CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    Bort A, Spínola E, Henche NR, Laviada ID (2017) Capsaicin exerts synergistic antitumor effect with sorafenib in hepatocellular carcinoma cells through AMPK activation. Oncotarget 8:87684–87698CrossRefPubMedPubMedCentralGoogle Scholar
  19. 19.
    Vani BKK (2017) Estimation of Capciacin content in different red chili varieties by UV – spectrophotometer. Carib J Sci Tech 5:025–031Google Scholar
  20. 20.
    Ryu WK, Kim HW, Kim GD, Rhee HI (2017) Rapid determination of capsaicinoids by colorimetric method. J Food Drug Anal 25:798–803CrossRefPubMedGoogle Scholar
  21. 21.
    Stipcovich T, Barbero GF, González MF, Palma M, Barroso CG (2018) Fast analysis of capsaicinoids in Naga Jolokia extracts (Capsicum chinense) by high-performance liquid chromatography using fused core columns. Food Chem 239:217–224CrossRefPubMedGoogle Scholar
  22. 22.
    Yang Q, Zhu J, Ma F, Li P, Zhang L, Zhang W, Ding X, Zhang Q (2016) Quantitative determination of major capsaicinoids in serum by ELISA and time-resolved fluorescent immunoassay based on monoclonal antibodies. Biosens Bioelectron 81:229–235CrossRefPubMedGoogle Scholar
  23. 23.
    Guo CL, Chen HY, Cui BL, Chen YH, Zhou YF, Peng XS, Wang Q (2015) Development of a HPLC method for the quantitative determination of capsaicin in collagen sponge. Int J Anal Chem 2015:1–6CrossRefGoogle Scholar
  24. 24.
    Lau BBY, Panchompoo J, Aldous L (2015) Extraction and electrochemical detection of capsaicin and ascorbic acid from fresh chilli using ionic liquids. New J Chem 39:860–867CrossRefGoogle Scholar
  25. 25.
    Wang L, Chen L, Luo T, Bao K, Qian Y (2006) A facile method to the cube-like MnSe2 microcrystallines via a hydrothermal process. Solid State Commun 138:72–75CrossRefGoogle Scholar
  26. 26.
    Meng M, Wu SX, Ren LZ, Zhou WQ, Wang YJ, Wang GL, Li SW (2014) Enlarged Mn 3s splitting and room-temperature ferromagnetism in epitaxially grown oxygen doped Mn2N0.86 films. J Appl Physiol 116:173911CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Electroanalysis and Bioelectrochemistry Lab, Department of Chemical Engineering and BiotechnologyNational Taipei University of TechnologyTaipeiTaiwan
  2. 2.Department of Botany and Microbiology, College of ScienceKing Saud UniversityRiyadhSaudi Arabia

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