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A specific fluorescent nanoprobe for dopamine based on the synergistic action of citrate and gold nanoparticles on Tb(III) luminescence

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Abstract

A nanoprobe was developed for the fluorometric determination of the neurotransmitter dopamine (DA). It is based on the synergistic enhancement action of citrate and gold nanoparticles (AuNPs) on the luminescence of Tb(III). AuNPs serve as substrates of surface enhanced fluorescence (SEF). Citrate, in turn, acts as a spacer for the SEF effect, a co-ligand of Tb(III) complex, and a recognizing component for DA. The synergistic action of citrate and AuNPs significantly increases the intrinsic green fluorescence of Tb(III) (best measured at excitation/emission peaks of 300/547 nm). Under the optimum conditions, the fluorescence intensity increases linearly in the 3.0 to 200 nM DA concentration ranging (with an R2 value of 0.9959), and the limit of detection (at S/N = 3) is 0.84 nM. The nanoprobe shows good selectivity for DA among other interfering neurotransmitters, some amino acids and ions. The method was applied to the detection of DA in human serum samples where it gave recoveries ranging from 100.5 to 102.9%.

Schematic of a Tb(III) composite fluorescent nanoprobe for the sensitive determination of dopamine (DA). Citrate and gold nanoparticles (AuNPs) synergistically enhance the fluorescence of Tb(III)-DA.

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Acknowledgements

This work was financially supported by National Natural Science Foundation of China (No. 21545001), Shandong Provincial Natural Science Foundation, China (No. ZR2018MB031) and Fundation of Logistics University of PVP (No. WHJ201601).

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Key Laboratory of Colloid and Interface Chemistry (Shandong University), Ministry of Education, Shandong University, Jinan, 250100, People’s Republic of China

    Chongmei Sun, Fangzheng Yuan & Xia Wu

  2. Logistics University of PAP, Tianjin, 300162, People’s Republic of China

    Huihui Li

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Correspondence to Xia Wu.

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Sun, C., Yuan, F., Li, H. et al. A specific fluorescent nanoprobe for dopamine based on the synergistic action of citrate and gold nanoparticles on Tb(III) luminescence. Microchim Acta 185, 317 (2018). https://doi.org/10.1007/s00604-018-2844-0

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