Nonenzymatic determination of glucose at near neutral pH values based on the use of nafion and platinum black coated microneedle electrode array
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The authors report on a microneedle-based amperometric nonenzymatic glucose sensor for painless and continuous monitoring of glucose. It consists of 3 × 5 sharp stainless steel microneedles micromachined from a stainless steel substrate. The microneedles are 600 and 100 μm in height and width, respectively. Nafion and platinum black were sequentially coated onto the tip of gold-coated microneedles and used for nonenzymatic (direct) sensing of glucose. Attractive features of the modified microneedle electrode include (a) a low working potential (+0.12 V vs. Ag/AgCl), (b) a linear response in the physiologically relevant range (1–40 mM), (c) a sensitivity as high as 175 μA mM−1 cm−2, (d) a 23 μM detection limit, and (e) a response time of 2 s. The sensor also exhibits good reproducibility and stability. The sensor is selective for glucose even in the presence of 10-fold higher concentrations of ascorbic acid, lactic acid, dopamine, uric acid, and acetaminophen.
KeywordsChloroplatinic acid hexahydrate Lead acetate Parylene Polydimethylsiloxane Electrochemical sensor Scanning electron microscope Chronoamperometry Cyclic voltammetry Electrodeposition
The work was supported by the National Research Foundation of Korea (No. NRF-2017R1D1A1A09000712, 2018R1C1B6009385, 2018M3A9F1023690).
Compliance with ethical standards
The author(s) declare that they have no competing interests.
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