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Microchimica Acta

, 185:170 | Cite as

Amperometric determination of myo-inositol by using a glassy carbon electrode modified with molecularly imprinted polypyrrole, reduced graphene oxide and nickel nanoparticles

  • Maísa Azevedo Beluomini
  • José Luiz da Silva
  • Nelson Ramos Stradiotto
Original Paper

Abstract

This paper reports on the development of an amperometric method for the determination of myo-inositol. The method involves coating of a glassy carbon electrode (GCE) with a molecularly imprinted polymer (MIP) and reduced graphene oxide (RGO) that was modified with nickel nanoparticles (NiNPs). The MIP was prepared by electropolymerization of pyrrole on the surface of the GCE in the presence of myo-inositol molecules. The construction steps of the modified electrode were monitored via cyclic voltammetry, atomic force microscopy, scanning electron microscopy and X-ray Photoelectron Spectroscopy. The results were evaluated using differential pulse voltammetry, in which hexacyanoferrate was used as an electrochemically active probe. Under optimized experimental conditions, the imprint-modified GCE has a linear response in the 1.0 × 10−10 mol L−1 to 1.0 × 10−8 mol L−1 concentration range, with a 7.6 × 10−11 mol L−1 detection limit and an electrochemical sensitivity of 4.5 μA·cm-2 μmol−1. The method showed improved selectivity even in the presence of molecules with similar chemical structure. The GCE modified was successfully applied to the determination of myo-inositol in sugarcane vinasse where it yielded recoveries that ranged from 95 to 102%.

Graphical abstract

Schematic presentation of molecularly imprinted polymer (MIP) on a glassy carbon electrode (GCE) modified with nickel nanoparticles (NiNP) anchored in reduced graphene oxide (RGO). The resulting MIP/NiNP/RGO-GCE was used for indirect determination of myo-inositol.

Keywords

Molecularly imprinted polymer Metallic nanoparticle Pyrrole Electropolymerization Electrochemical determination Polyol compounds 

Notes

Acknowledgements

Our sincerest gratitude to the Brazilian Research Funding Agencies – São Paulo Research Foundation (FAPESP) process n° 2014/23846-5 and Coordination for the Improvement of Higher Education Personnel (process n° 33004030072p8) for the financial support granted in the course of this research.

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2018_2710_MOESM1_ESM.docx (2.8 mb)
ESM 1 (DOCX 2851 kb)

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  • Maísa Azevedo Beluomini
    • 1
  • José Luiz da Silva
    • 1
  • Nelson Ramos Stradiotto
    • 1
    • 2
    • 3
  1. 1.Institute of ChemistrySão Paulo State University (UNESP)AraraquaraBrazil
  2. 2.Bioenergy Research InstituteSão Paulo State University (UNESP)Rio ClaroBrazil
  3. 3.School of Metallurgical and Industrial Engineering, Volta RedondaFluminense Federal University (UFF)Volta RedondaBrazil

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