Microchimica Acta

, 185:148 | Cite as

A stir foam composed of graphene oxide, poly(ethylene glycol) and natural latex for the extraction of preservatives and antioxidant

  • Charinrat Siritham
  • Chongdee Thammakhet-Buranachai
  • Panote Thavarungkul
  • Proespichaya KanatharanaEmail author
Original Paper


A stir foam composed of graphene oxide, poly(ethylene glycol) and natural latex (GO-PEG-NL) was prepared for use in micro-solid phase extraction sorbent of preservative agents and antioxidants from cosmetic products. The extracted analytes were quantified by GC-MS. Under the optimized conditions, the calibration plots are linear in the concentration ranges between 5.0 μg·L−1 to 1.0 mg·L−1 for benzoic acid, of 10.0 μg·L−1 to 1.0 mg·L−1 for 2-methyl-3-isothiazolinone (MI), and between 1.0 μg·L−1 and 1.0 mg·L−1 for both 3-tert-butyl-4-hydroxyanisole (BHA) and 2,6-di-tert-butyl-p-hydroxytoluene (BHT). The LODs are 1.0 μg·L−1 for benzoic acid, 5.0 μg·L−1 for MI and 0.5 μg·L−1 for both BHA and BHT. The stir-foam can be easily prepared, is inexpensive and well reproducible (RSDs <3%, for n = 6). It can be re-used for up to 12 times after which extraction efficiency has dropped to 90%. The method was successfully applied to the determination of preservatives and antioxidants in cosmetic samples. Recoveries from spiked samples ranged between 94.5 ± 2.1% and 99.8 ± 1.8%.

Graphical abstract

A stir foam was prepared from graphene oxide, poly(ethylene glycol) and natural latex (GO-PEG-NL) and is shown to be a most viable sorbent for the microextraction of trace amounts of preservative agents and antioxidants from cosmetic products.


Micro-solid phase extraction BHA BHT Cosmetics MI Porous sorbent 



This project was supported by the Thailand Research Fund, Faculty of Science and Prince of Songkla University (BRG6080009); the Center of Excellence for Innovation in Chemistry (PERCH-CIC); the Trace Analysis and Biosensor Research Center (TAB-RC), Prince of Songkla University; Department of Chemistry, Faculty of Science and Graduate School, Prince of Songkla University, Hat Yai, Songkhla. Financial support for Charinrat Siritham from Prince of Songkla University Ph.D. Scholarship is also gratefully acknowledged. The authors would also like to thank Asst. Prof. Dr. Ekwipoo Kalkornsurapranee for preparation of natural latex foam and Mr. Thomas Duncan Coyne for his help in preparing the manuscript.

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2017_2643_MOESM1_ESM.docx (963 kb)
ESM 1 (DOCX 963 kb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  • Charinrat Siritham
    • 1
    • 2
    • 3
  • Chongdee Thammakhet-Buranachai
    • 1
    • 2
    • 3
  • Panote Thavarungkul
    • 1
    • 2
    • 4
  • Proespichaya Kanatharana
    • 1
    • 2
    • 3
    Email author
  1. 1.Trace Analysis and Biosensor Research CenterPrince of Songkla UniversityHat YaiThailand
  2. 2.Center of Excellence for Innovation in Chemistry, Faculty of SciencePrince of Songkla UniversityHat YaiThailand
  3. 3.Department of Chemistry, Faculty of SciencePrince of Songkla UniversityHat YaiThailand
  4. 4.Department of Physics, Faculty of SciencePrince of Songkla UniversityHat YaiThailand

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