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Simultaneous determination of captopril and hydrochlorothiazide by using a carbon ionic liquid electrode modified with copper hydroxide nanoparticles

Microchimica Acta volume 185, Article number: 97 (2018) Cite this article

Abstract

A carbon electrode modified with the ionic liquid octylpyridinium hexafluorophosphate and copper hydroxide nanoparticles was employed in an electrochemical assay for simultaneous determination of captopril (CPT) and hydrochlorothiazide (HCT). The electrode showed two well-defined oxidation peaks for CPT (at 0.22 V) and HCT (at 0.73 V, both vs. Ag/AgCl) at pH 8.0 using square wave voltammetry. Calibration plots are linear in the concentration ranges of 0.7–70 µM (CPT) and 3–600 μM (HCT), with detection limits of 12 and 60 nM, respectively. The electrode was repeatedly applied to simultaneous determination of CPT and HCT in pharmaceutical formulation without showing any fouling.

Application of carbon ionic liquid electrode (CILE) modified with Cu(OH)2 nanoparticles (Cu(OH)2NP/CILE) for the simultaneous determination of captopril (CPT) and hydrochlorothiazide (HCT) in pharmaceutical formulation is presented.

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Acknowledgements

A grateful acknowledgment is made to Shiraz University Research Council for supporting this research. The authors thank Daroo-Pakhsh pharmaceutical Co. (Iran) for donating the studied drugs. We also appreciate the assistance of Miss Raheleh Ahmadi due to her technical guidance.

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  1. Department of Chemistry, College of Sciences, Shiraz University, P. O. Box, Shiraz, 71454, Iran

    Ghodratollah Absalan, Morteza Akhond, Raziye Karimi & Amir M. Ramezani

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  1. Ghodratollah Absalan
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  2. Morteza Akhond
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  3. Raziye Karimi
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  4. Amir M. Ramezani
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Correspondence to Ghodratollah Absalan.

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Absalan, G., Akhond, M., Karimi, R. et al. Simultaneous determination of captopril and hydrochlorothiazide by using a carbon ionic liquid electrode modified with copper hydroxide nanoparticles. Microchim Acta 185, 97 (2018). https://doi.org/10.1007/s00604-017-2630-4

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  • DOI: https://doi.org/10.1007/s00604-017-2630-4

Keywords

  • Cyclic voltammetry
  • Electrochemical assay
  • Electrochemical determination
  • Nanomaterial
  • Octyl pyridinium hexafluorophosphate
  • Pharmaceutical dosage
  • Square wave voltammetry
  • Tablet analysis
  • TEM
  • XRD