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Photocatalytic self-cleaning electrochemical sensor for honokiol based on a glassy carbon electrode modified with reduced graphene oxide and titanium dioxide

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Abstract

The authors describe the construction of a renewable electrochemical method for determination of honokiol in complex traditional Chinese herbs. A nanocomposite consisting of reduced graphene oxide and titanium dioxide was prepared and deposited on the surface of a glassy carbon electrode (GCE). This composite endows the GCE with self-cleaning capability via ultraviolet illumination. Under optimized conditions and at a typical working voltage of 0.54 V (vs. Ag/AgCl), the sensor has a linear response in the 0.025 to 10 μmol·L−1 honokinol concentration range, and the detection limit is 20 nmol·L−1 (at an S/N ratio of 3). The method was successfully applied to the determination of honokiol in cortex herbs and its galenicals.

Schematic of a photocatalytic self-cleaning electrochemical sensor based on reduced graphene oxide and titanium dioxide for honokiol detection. The method has successfully been applied to the determination of honokiol in Chinese herbs with satisfied results.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (Nos. 21475034 and 21675041) and the National Science and Technology Major Project for “Major New Drugs Innovation and Development” (no. 2014ZX09304307001-021).

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Authors and Affiliations

  1. School of Laboratory Medicine, Hubei University of Chinese Medicine, 1 Huangjia Lake West Road, Wuhan, 430065, People’s Republic of China

    Yan Lei, Fan Yang, Yu-Tao Li, Lina Tang & Guo-Jun Zhang

  2. School of Pharmacy, Hubei University of Chinese Medicine, 1 Huangjia Lake West Road, Wuhan, 430065, People’s Republic of China

    Yan Lei & Keli Chen

  3. Department of Pharmacy, Huangshi Central Hospital of Edong Healthcare Group, Affiliated Hospital of Hubei Polytechnic University, 3 Tianjin Road 141, Huangshi, 435000, Hubei, People’s Republic of China

    Yan Lei

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  1. Yan Lei
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  2. Fan Yang
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  3. Yu-Tao Li
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  4. Lina Tang
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Correspondence to Keli Chen or Guo-Jun Zhang.

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Lei, Y., Yang, F., Li, YT. et al. Photocatalytic self-cleaning electrochemical sensor for honokiol based on a glassy carbon electrode modified with reduced graphene oxide and titanium dioxide. Microchim Acta 184, 2299–2305 (2017). https://doi.org/10.1007/s00604-017-2239-7

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  • DOI: https://doi.org/10.1007/s00604-017-2239-7

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