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A nanocomposite consisting of carbon nanotubes and gold nanoparticles in an amphiphilic copolymer for voltammetric determination of dopamine, paracetamol and uric acid

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Abstract

The amphiphilic copolymer poly(vinylbenzyl thymine-co-styrene-co-maleic anhydride) (PSVM) was synthesized by radical copolymerization of styrene, vinylbenzyl thymine, and maleic anhydride. Its chemical structure was proven by using 1H nuclear magnetic resonance spectroscopy. PSVM was used as a host to prepare a composite consisting of carbon nanotubes and gold nanoparticles by in-situ reduction. The morphology of the nanocomposites was studied by transmission electron microscopy. A glassy carbon electrode coated with this composite is shown to be a viable sensor for the determination of dopamine (DA), paracetamol (PAT) (both at a pH value of 7), and uric acid (UA) (at pH 6). Two linear relationships exists between amperometric current and analyte concentrations. For DA, the linear analytical ranges are from 0.1 to 200 μM and from 200 to 1000 μM. For PAT, the ranges are from 0.1 to 200 μM and from 200 to 1000 μM. For UA, the ranges are from 0.05 to 1000 μM. The respective limits of detection (for S/N = 3) are 56, 27 and 50 nM. The sensor is highly sensitive, stable, reproducible, and selective.

A hybrid nanocomposite (CNT/PSVM/Au) of carbon nanotube (CNT) – Au nanoparticle composite based on the amphiphilic copolymer poly(vinylbenzyl thymine/styrene-co-maleic anhydride) (PSVM) was prepared through in situ reduction. This nanocomposite was immobilized on a glassy carbon electrode (GCE) to fabricate an electrochemical sensor to determine dopamine (DA), paracetamol (PAT) and uric acid (UA).

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Acknowledgements

We acknowledge financial support from the National Nature Science Foundation of Jiangsu Province (No. BK20140160), Innovation Foundation of Jiangsu (No. BY2015019-14) and the Fundamental Research Funds for the Central Universities (JUSRP11514).

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Authors and Affiliations

  1. The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu, 214122, China

    Jingcheng Liu, Yazhen Xie, Kuan Wang, Qingtao Zeng, Ren Liu & Xiaoya Liu

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  1. Jingcheng Liu
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  2. Yazhen Xie
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  3. Kuan Wang
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  4. Qingtao Zeng
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  5. Ren Liu
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Correspondence to Jingcheng Liu.

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Liu, J., Xie, Y., Wang, K. et al. A nanocomposite consisting of carbon nanotubes and gold nanoparticles in an amphiphilic copolymer for voltammetric determination of dopamine, paracetamol and uric acid. Microchim Acta 184, 1739–1745 (2017). https://doi.org/10.1007/s00604-017-2185-4

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