Magnetic carbon nanotubes modified with 1,4-diazabicyclo[2.2.2] octane are a viable sorbent for extraction of selective serotonin reuptake inhibitors
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Carbon nanotubes were modified with magnetite nanoparticles, and 1,4-diazabicyclo[2.2.2]octane (DABCO) was then covalently attached to their surface. The resulting material is shown to be a viable sorbent for the preconcentration of the selective serotonin reuptake inhibitors citalopram, sertraline, fluvoxamine and fluoxetine via ultrasound-assisted magnetic solid phase extraction. The effects of pH value, sorbent dosage, eluent volume and salt concentration were optimized by central composite design and desirability function. The drugs were quantified by HPLC with UV detection. Detection limits are as low as 0.2, 0.25, 0.3, and 0.5 ng mL−1 for citalopram, sertraline, fluvoxamine and fluoxetine, respectively. The intra-day precisions (RSDs) are <4.0%. The method was applied to the determination of the selective serotonin reuptake inhibitors in plasma samples and gave recoveries of >91%. The sorbent can be reused 12 times without a noticeable decrease in extraction efficiency.
KeywordsMagnetite nanoparticles Preconcentration Solid phase extraction Central composite design
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The author(s) declare that they have no competing interests.
- 1.Golbabanezhadazizi A, Ranjbari E, Hadjmohammadi M, Daneshinejad H (2016) Determination of selective serotonin reuptake inhibitors in biological samples via magnetic stirring-assisted dispersive liquid–liquid microextraction followed by high performance liquid chromatography. RSC Advances 6:50,710CrossRefGoogle Scholar
- 2.Vázquez MP, Vázquez PP, Galera MM, García MG, Uclés A (2013) Ultrasound-assisted ionic liquid dispersive liquid–liquid microextraction coupled with liquid chromatography-quadrupole-linear ion trap-mass spectrometry for simultaneous analysis of pharmaceuticals in wastewaters. J Chromatogr A 1291:19CrossRefGoogle Scholar
- 3.Vazquez MP, Vazquez PP, Galera MM, Moreno AU (2014) Comparison of two ionic liquid dispersive liquid–liquid microextraction approaches for the determination of benzoylurea insecticides in wastewater using liquid chromatography–quadrupole-linear ion trap–mass spectrometry: Evaluation of green parameters. J Chromatogr A 1356:1CrossRefGoogle Scholar
- 6.He H, Yuan D, Gao Z, Xiao D, He H, Dai H, Peng J, Li N (2014) Mixed hemimicelles solid-phase extraction based on ionic liquid-coated Fe3O4/SiO2 nanoparticles for the determination of flavonoids in bio-matrix samples coupled with high performance liquid chromatography. J Chromatogr A 1324:78CrossRefGoogle Scholar
- 17.Davarpanah J, Kiasat AR, Noorizadeh S, Ghahremani M (2013) Nano magnetic double-charged diazoniabicyclo [2.2.2] octane dichloride silica hybrid: Synthesis, characterization, and application as an efficient and reusable organic–inorganic hybrid silica with ionic liquid framework for one-pot synthesis of pyran annulated heterocyclic compounds in water. J Mol Catal A: Chem 376:78CrossRefGoogle Scholar
- 19.Ghazaghi M, Mousavi HZ, Shirkhanloo H, Rashidi A (2016) Ultrasound assisted dispersive micro solid-phase extraction of four tyrosine kinase inhibitors from serum and cerebrospinal fluid by using magnetic nanoparticles coated with nickel-doped silica as an adsorbent. Microchim Acta 183:2779CrossRefGoogle Scholar
- 21.Viking G (1998) A compromise approach to multiresponse optimization. J Qual Technol 30:309Google Scholar
- 30.Wille SM, Van Hee P, Neels HM, Van Peteghem CH, Lambert WE (2007) Comparison of electron and chemical ionization modes by validation of a quantitative gas chromatographic–mass spectrometric assay of new generation antidepressants and their active metabolites in plasma. J Chromatogr A 1176:236CrossRefGoogle Scholar