Microchimica Acta

, Volume 184, Issue 5, pp 1427–1436 | Cite as

Magnetic carbon nanotubes modified with 1,4-diazabicyclo[2.2.2] octane are a viable sorbent for extraction of selective serotonin reuptake inhibitors

  • Zahra Lotfi
  • Hassan Zavvar Mousavi
  • S. Maryam Sajjadi
Original Paper


Carbon nanotubes were modified with magnetite nanoparticles, and 1,4-diazabicyclo[2.2.2]octane (DABCO) was then covalently attached to their surface. The resulting material is shown to be a viable sorbent for the preconcentration of the selective serotonin reuptake inhibitors citalopram, sertraline, fluvoxamine and fluoxetine via ultrasound-assisted magnetic solid phase extraction. The effects of pH value, sorbent dosage, eluent volume and salt concentration were optimized by central composite design and desirability function. The drugs were quantified by HPLC with UV detection. Detection limits are as low as 0.2, 0.25, 0.3, and 0.5 ng mL−1 for citalopram, sertraline, fluvoxamine and fluoxetine, respectively. The intra-day precisions (RSDs) are <4.0%. The method was applied to the determination of the selective serotonin reuptake inhibitors in plasma samples and gave recoveries of >91%. The sorbent can be reused 12 times without a noticeable decrease in extraction efficiency.

Graphical abstract

Magnetic carbon nanotubes were modified with 1,4-diazabicyclo[2.2.2]octane (DABCO) with ionic liquid framework. Resulting material was used as a reusable and selective sorbent for preconcentration and extraction of antidepressant drugs from plasma samples.


Magnetite nanoparticles Preconcentration Solid phase extraction Central composite design 


Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2017_2150_MOESM1_ESM.docx (4.9 mb)
ESM 1 (DOCX 4970 kb)


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Copyright information

© Springer-Verlag Wien 2017

Authors and Affiliations

  • Zahra Lotfi
    • 1
  • Hassan Zavvar Mousavi
    • 1
  • S. Maryam Sajjadi
    • 1
  1. 1.Department of Chemistry, College of ScienceSemnan UniversitySemnanIran

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