Graphene micro-aerogel based voltammetric sensing of p-acetamidophenol
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The authors describe a method for the fabrication of graphene micro-aerogels (GMA) using a multiple emulsion as a soft template. A mixed surfactant consisting of polymannitol oleate ester and polyoxyethylene castor oil was dissolved in toluene. An aqueous dispersion of graphene oxide was dropped into the above solution to produce a water-in-oil-in-water multiple emulsion. Hydrazine was used to reduce the graphene oxide. The partly reduced sheets of graphene oxide diffuse into the oil phase due to their low polarity. This induces the self-assembly of graphene sheets at the oil-water interface to finally form GMA. Following freeze drying and thermal annealing at 900 °C under Ar/H2, GMA is obtained which possesses a microcapsule-like structure, high electrical conductivity (3250 S m−1), a large specific surface (1253 m2 g−1) and a well-defined porous structure. A glassy carbon electrode modified with the GMA shows ultrahigh sensitivity for the electrochemical detection of p-acetamidophenol. The differential pulse voltammetric peak current increases linearly over the 1 × 10−8 to 8.0 × 10−5 M p-acetamidophenol concentration range, and the detection limit is 5.7 × 10−9 M (at an S/N ratio of 3). The sensitivity is much better than that of sensors based on the use of graphene, graphene aerogel, or high density graphene aerogel. The method was successfully applied to the determination of p-acetamidophenol in tablets. The study also provides promising prospects in terms of graphene aerogel materials with improved electrochemical performance in electrocatalysis, supercapacitors and lithium ion batteries.
KeywordsAerogel Paracetamol Differential pulse voltammetry Microcapsules Water-in-oil-in-water emulsion Drug analysis
The authors acknowledge the financial support from the National Natural Science Foundation of China (No. 21576115), Prospective Joint Research Project: Cooperative Innovation Fund (No. BY2015019-26) and MOE & SAFEA for the 111 Project (B13025).
Compliance with ethical standards
The author(s) declare that they have no competing interests.
- 5.Sawangphruk M, Krittayavathananon A, Chinwipas N, Srimuk P, Vatanatham T, Limtrakul S, Foord JS (2013) Ultraporous palladium supported on graphene-coated carbon fiber paper as a highly active catalyst electrode for the oxidation of methanol. Fuel Cells 13:881–888Google Scholar
- 21.Gao LB, Ren WC, Xu HL, Jin L, Wang ZX, Ma T, Ma LP, Zhang ZY, Fu Q, Peng LM, Bao XH, Cheng HM (2012) Repeated growth and bubbling transfer of graphene with millimetre-size single-crystal grains using platinum. Nat Commu 3: 699–1–699-7.Google Scholar
- 26.Karimi-Maleh H, Hatami M, Moradi R, Khalilzadeh MA, Amiri S, Sadeghifar H (2016) Synergic effect of Pt-Co nanoparticles and a dopamine derivative in a nanostructured electrochemical sensor for simultaneous determination of N-acetylcysteine, paracetamol and folic acid. Microchim Acta 183:2957–2964CrossRefGoogle Scholar
- 33.Hinostroza Ramos JV, Matos Morawski FD, Haas Costa TM, Pereira Dias SL, Benvenutti EV, Menezes EWD, Arenas LT (2015) Mesoporous chitosan/silica hybrid material applied for development of electrochemical sensor for paracetamol in presence of dopamine. Microporous Mesoporous Mater 217:109–118CrossRefGoogle Scholar