Microchimica Acta

, Volume 184, Issue 5, pp 1285–1294 | Cite as

Highly sensitive and selective voltammetric determination of dopamine using a gold electrode modified with a molecularly imprinted polymeric film immobilized on flaked hollow nickel nanospheres

  • Yuan Liu
  • Jie Liu
  • Jiang Liu
  • Wei Gan
  • Bang-ce Ye
  • Yingchun Li
Original Paper


The authors describe the preparation of a molecularly imprinted polymer (MIP) film on the surface of electrodeposited hollow nickel nanospheres (hNiNS), and the use of this nanocomposite in an electrochemical sensor for dopamine (DA). The use of the 3-dimensional hNiNS as a support material enlarges the sensing area and conductivity, while the MIP film warrants improved selectivity for DA. Quantification based on the “MIP/gate effect” was performed by employing hexacyanoferrate as the electrochemical probe. Scanning electron microscopy, cyclic voltammetry and electrochemical impedance spectroscopy were applied to characterize the sensor materials. The electropolymerization condition such as pH value, functional monomer and ratio of template to monomer were optimized. By using dopamine (DA) as a model analyte, the sensor, if operated at 0.1 V vs. SCE, has fairly low detection limit of 1.7 × 10−14 M (at an S/N ratio of 3), two wide assay ranges of 5 × 10−14 to 1 × 10−12 M and 1 × 10−12 to 5 × 10−11 M, and superb selectivity.

Graphical Abstract

An electrochemical sensor platform with a novel composite film composed of hollow nickel nanospheres (hNiNS) and molecularly imprinted polymer (MIP) was developed via a facile double-elecrodeposition method. The synergistic effects of hNiNS and MIP guarantee the ultrahigh sensitivity (down to 10−2 ppt) and selectivity of the sensor.


Electrochemical sensor Cyclic voltammetry Electrochemical impedance spectroscopy MIP Electropolymerization Blood analysis Trace assay Nanocomposite Gate effect Hexacyanoferrate 



The project financially supported by National Natural Science Foundation of China (81460543, 21575089) and 2015 Key Technical Innovation Project of Xinjiang Uygur Autonomous Region.

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2017_2124_MOESM1_ESM.doc (1.8 mb)
ESM 1 (DOC 1.75 mb)


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Copyright information

© Springer-Verlag Wien 2017

Authors and Affiliations

  • Yuan Liu
    • 1
  • Jie Liu
    • 2
  • Jiang Liu
    • 1
  • Wei Gan
    • 1
  • Bang-ce Ye
    • 3
    • 4
  • Yingchun Li
    • 1
    • 2
    • 3
  1. 1.School of ScienceHarbin Institute of Technology (Shenzhen)ShenzhenChina
  2. 2.Key Laboratory of Xinjiang Phytomedicine Resources for Ministry of Education, School of Pharmacy, School of PharmacyShihezi UniversityShiheziChina
  3. 3.Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical EngineeringShihezi UniversityShiheziChina
  4. 4.State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghaiChina

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