Advertisement

Microchimica Acta

, Volume 184, Issue 5, pp 1463–1470 | Cite as

A boronic acid based glucose assay based on the suppression of the inner filter effect of gold nanoparticles on the orange fluorescence of graphene oxide quantum dots

Original Paper

Abstract

The authors describe a non-enzymatioc glucose assay that has three features: (a) The use of a boronic acid as the recognition element; (b) the aggregation of gold nanoparticles (AuNPs), and (c) the use of graphene oxide quantum dots (GOQD) whose fluorescence matches the absorption of the AuNPs and thereby results in an inner filter effect (IFE). The GOQD display an orange colored fluorescence that is filtered off by the AuNPs due to an IFE. In the presence of 3-aminobenzeneboronic acid, glucose is bound to form a cationic species that causes the aggregation of AuNPs to form large assemblies. This is accompanied by a color change from red to blue, and the IFE no longer does occur so that the orange fluorescence of the GOQD pops up again. These findings were used to design an assay witha linear response in the  2.5 to 75 μmol L−1 glucose concentration range, with a detection limit of 0.65 μmol L−1. The method was applied to the determination of glucose in spiked diluted serum and gave satisfactory results.

Graphical abstract

Schematic of the detection of glucose based on inner filter effect of dispersed AuNPs on the orange fluorescence of graphene oxide quantum dots.

Keywords

Carbonaceous nanomaterial Fluorescence Aggregation assay Glucose Molecular recognition Serum analysis 

Notes

Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (Nos. 21075050 and 21275063), the Science and Technology Development project of Jilin province, China (No. 20150204010GX).

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2017_2090_MOESM1_ESM.doc (6.3 mb)
ESM 1 (DOC 6411 kb)

References

  1. 1.
    Yang J, Cho M, Lee Y (2016) Synthesis of hierarchical Ni(OH)(2) hollow nanorod via chemical bath deposition and its glucose sensing performance. Sensors Actuators B Chem 222:674–681CrossRefGoogle Scholar
  2. 2.
    Yu Z, Li H, Zhang X, Liu N, Tan W, Zhang X, Zhang L (2016) Facile synthesis of NiCo2O4@polyaniline core-shell nanocomposite for sensitive determination of glucose. Biosens Bioelectron 75:161–165CrossRefGoogle Scholar
  3. 3.
    Chen J, Ge J, Zhang L, Li Z, Qu L (2016) Poly(styrene sulfonate) and Pt bifunctionalized graphene nanosheets as an artificial enzyme to construct a colorimetric chemosensor for highly sensitive glucose detection. Sensors Actuators B Chem 233:438–444CrossRefGoogle Scholar
  4. 4.
    Steiner M-S, Duerkop A, Wolfbeis OS (2011) Optical methods for sensing glucose. Chem Soc Rev 40(9):4805–4839CrossRefGoogle Scholar
  5. 5.
    Fan Y, Tan X, Liu X, Ou X, Chen S, Wei S (2015) A novel non-enzymatic electrochemiluminescence sensor for the detection of glucose based on the competitive reaction between glucose and phenoxy dextran for concanavalin a binding sites. Electrochim Acta 180:471–478CrossRefGoogle Scholar
  6. 6.
    Gao ZF, Chen DM, Lei JL, Luo HQ, Li NB (2015) A regenerated electrochemical biosensor for label-free detection of glucose and urea based on conformational switch of i-motif oligonucleotide probe. Anal Chim Acta 897:10–16CrossRefGoogle Scholar
  7. 7.
    Fang X, Wu X-M, Hu X-L, Li Z-J, Wang G-L (2016) Native carbon nanodots as a fluorescent probe for assays based on the use of glucose oxidase or horseradish peroxidase. Microchim Acta 183(10):2761–2770CrossRefGoogle Scholar
  8. 8.
    Durán GM, Benavidez TE, Ríos Á, García CD (2016) Quantum dot-modified paper-based assay for glucose screening. Microchim Acta 183(2):611–616CrossRefGoogle Scholar
  9. 9.
    Sodzel D, Khranovskyy V, Beni V, Turner APF, Viter R, Eriksson MO, Holtz P-O, Janot J-M, Bechelany M, Balme S, Smyntyna V, Kolesneva E, Dubovskaya L, Volotovski I, Ubelis A, Yakimova R (2015) Continuous sensing of hydrogen peroxide and glucose via quenching of the UV and visible luminescence of ZnO nanoparticles. Microchim Acta 182(9):1819–1826CrossRefGoogle Scholar
  10. 10.
    Ding C, Yan Y, Xiang D, Zhang C, Xian Y (2016) Magnetic Fe3S4 nanoparticles with peroxidase-like activity, and their use in a photometric enzymatic glucose assay. Microchim Acta 183(2):625–631CrossRefGoogle Scholar
  11. 11.
    Çiftçi H, Alver E, Çelik F, Metin AÜ, Tamer U (2016) Non-enzymatic sensing of glucose using a glassy carbon electrode modified with gold nanoparticles coated with polyethyleneimine and 3-aminophenylboronic acid. Microchim Acta 183(4):1479–1486CrossRefGoogle Scholar
  12. 12.
    Tan L, Chen K, Huang C, Peng R, Luo X, Yang R, Cheng Y, Tang Y (2015) A fluorescent turn-on detection scheme for α-fetoprotein using quantum dots placed in a boronate-modified molecularly imprinted polymer with high affinity for glycoproteins. Microchim Acta 182(15):2615–2622CrossRefGoogle Scholar
  13. 13.
    Adolfsson KH, Hassanzadeh S, Hakkarainen M (2015) Valorization of cellulose and waste paper to graphene oxide quantum dots. RSC Adv 5(34):26550–26558CrossRefGoogle Scholar
  14. 14.
    He Y, Sun J, Feng D, Chen H, Gao F, Wang L (2015) Graphene quantum dots: highly active bifunctional nanoprobes for nonenzymatic photoluminescence detection of hydroquinone. Biosens Bioelectron 74:418–422CrossRefGoogle Scholar
  15. 15.
    Du X, Jiang D, Liu Q, Zhu G, Mao H, Wang K (2015) Fabrication of graphene oxide decorated with nitrogen-doped graphene quantum dots and its enhanced electrochemiluminescence for ultrasensitive detection of pentachlorophenol. Analyst 140(4):1253–1259.SCrossRefGoogle Scholar
  16. 16.
    Benitez-Martinez S, Valcarcel M (2015) Fluorescent determination of graphene quantum dots in water samples. Anal Chim Acta 896:78–84CrossRefGoogle Scholar
  17. 17.
    Zhang L, Peng D, Liang R-P, Qiu J-D (2015) Graphene quantum dots assembled with Metalloporphyrins for "turn on" sensing of hydrogen peroxide and glucose. Chem Eur J 21(26):9343–9348CrossRefGoogle Scholar
  18. 18.
    Pei H, Zhu S, Yang M, Kong R, Zheng Y, Qu F (2015) Graphene oxide quantum dots@silver core-shell nanocrystals as turn-on fluorescent nanoprobe for ultrasensitive detection of prostate specific antigen. Biosens Bioelectron 74:909–914CrossRefGoogle Scholar
  19. 19.
    Abnous K, Danesh NM, Ramezani M, Emrani AS, Taghdisi SM (2016) A novel colorimetric sandwich aptasensor based on an indirect competitive enzyme-free method for ultrasensitive detection of chloramphenicol. Biosens Bioelectron 78:80–86CrossRefGoogle Scholar
  20. 20.
    Xianyu Y, Xie Y, Wang N, Wang Z, Jiang X (2015) A dispersion-dominated chromogenic strategy for colorimetric sensing of glutathione at the Nanomolar level using gold nanoparticles. Small 11(41):5510–5514CrossRefGoogle Scholar
  21. 21.
    Xia N, Zhou B, Huang N, Jiang M, Zhang J, Liu L (2016) Visual and fluorescent assays for selective detection of beta-amyloid oligomers based on the inner filter effect of gold nanoparticles on the fluorescence of CdTe quantum dots. Biosens Bioelectron 85:625–632CrossRefGoogle Scholar
  22. 22.
    Liu Z, Liu H, Wang L, Su X (2016) A label-free fluorescence biosensor for highly sensitive detection of lectin based on carboxymethyl chitosan-quantum dots and gold nanoparticles. Anal Chim Acta 932:88–97CrossRefGoogle Scholar
  23. 23.
    Zhao W, Brook MA, Li Y (2008) Design of Gold Nanoparticle-Based Colorimetric Biosensing Assays. Chembiochem 9(15):2363–2371CrossRefGoogle Scholar
  24. 24.
    Lou J, Liu S, Tu W, Dai Z (2015) Graphene Quantums dots combined with endonuclease cleavage and bidentate chelation for highly sensitive Electrochemiluminescent DNA Biosensing. Anal Chem 87(2):1145–1151CrossRefGoogle Scholar
  25. 25.
    Song L, Shi J, Lu J, Lu C (2015) Structure observation of graphene quantum dots by single-layered formation in layered confinement space. Chem Sci 6(8):4846–4850CrossRefGoogle Scholar
  26. 26.
    Vasu KS, Sridevi S, Sampath S, Sood AK (2015) Non-enzymatic electronic detection of glucose using aminophenylboronic acid functionalized reduced graphene oxide. Sensors Actuators B Chem 221:1209–1214CrossRefGoogle Scholar
  27. 27.
    Qian S, Liang Y, Ma J, Zhang Y, Zhao J, Peng W (2015) Boronic acid modified fiber optic SPR sensor and its application in saccharide detection. Sensors Actuators B Chem 220:1217–1223CrossRefGoogle Scholar
  28. 28.
    Cayuela A, Soriano ML, Valcarcel M (2015) Reusable sensor based on functionalized carbon dots for the detection of silver nanoparticles in cosmetics via inner filter effect. Anal Chim Acta 872:70–76CrossRefGoogle Scholar
  29. 29.
    Wu Q, Wang X, Liao C, Wei Q, Wang Q (2015) Microgel coating of magnetic nanoparticles via bienzyme-mediated free-radical polymerization for colorimetric detection of glucose. Nanoscale 7(40):16578–16582CrossRefGoogle Scholar
  30. 30.
    Xiong Y, Zhang Y, Rong P, Yang J, Wang W, Liu D (2015) A high-throughput colorimetric assay for glucose detection based on glucose oxidase-catalyzed enlargement of gold nanoparticles. Nanoscale 7(38):15584–15588CrossRefGoogle Scholar
  31. 31.
    Wang Y, Zhang S, Bai W, Zheng J (2016) Layer-by-layer assembly of copper nanoparticles and manganese dioxide-multiwalled carbon nanotubes film: a new nonenzymatic electrochemical sensor for glucose. Talanta 149:211–216CrossRefGoogle Scholar
  32. 32.
    Fang L, Liu B, Liu L, Li Y, Huang K, Zhang Q (2016) Direct electrochemistry of glucose oxidase immobilized on Au nanoparticles-functionalized 3D hierarchically ZnO nanostructures and its application to bioelectrochemical glucose sensor. Sensors Actuators B Chem 222:1096–1102CrossRefGoogle Scholar
  33. 33.
    Qu F, Guo X, Liu D, Chen G, You J (2016) Dual-emission carbon nanodots as a ratiometric nanosensor for the detection of glucose and glucose oxidase. Sensors Actuators B Chem 233:320–327CrossRefGoogle Scholar
  34. 34.
    Lerner MB, Kybert N, Mendoza R, Villechenon R, Bonilla Lopez MA, Charlie Johnson AT (2013) Scalable, non-invasive glucose sensor based on boronic acid functionalized carbon nanotube transistors. Appl Phys Lett 102(18):183113CrossRefGoogle Scholar
  35. 35.
    Zhao YQ, Luo HQ, Li NB (2009) Electrochemical characterization of in situ functionalized gold p-aminothiophenol self-assembled monolayer with 4-formylphenylboronic acid for recognition of sugars. Sensors Actuators B Chem 137(2):722–726CrossRefGoogle Scholar
  36. 36.
    Badhulika S, Tlili C, Mulchandani A (2014) Poly(3-aminophenylboronic acid)-functionalized carbon nanotubes-based chemiresistive sensors for detection of sugars. Analyst 139(12):3077–3082CrossRefGoogle Scholar
  37. 37.
    Tang X, Zhang B, Xiao C, Zhou H, Wang X, He D (2016) Carbon nanotube template synthesis of hierarchical NiCoO2 composite for non-enzyme glucose detection. Sensors Actuators B Chem 222:232–239CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 2017

Authors and Affiliations

  • Weidan Na
    • 1
  • Hua Liu
    • 1
  • Mingyue Wang
    • 1
  • Xingguang Su
    • 1
  1. 1.Department of Analytical Chemistry, College of ChemistryJilin UniversityChangchunChina

Personalised recommendations