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Electrochemically modified carbon fiber bundles as selective sorbent for online solid-phase microextraction of sulfonamides

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Abstract

The authors show that carbon fiber bundles electrochemically modified with the conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) is a viable sorbent for online solid-phase microextraction (SPME) of the sulfonamides (sulfadiazine, sulfadimidine and sulfamethoxazole) prior to their determination by HPLC. The fibers were packed in a tube loop made from polyether ether ketone (PEEK) that was coupled to the HPLC system for online SPME. Preconcentration factors can reach values of up to 300, and the limit of detection (at an S/N ration of 3) can be as low as 0.05 ng⋅mL−1. The method was applied to the analysis of the sulfonamides in spiked rat plasma with intra-day and inter-day RSDs of <3.33 and <4.57 %, and with recoveries in the range from 91.7 to 97.8 % in spiked plasma. The in-tube SPME was also applied to the determination of the 3 sulfonamides in rat plasma after oral administration (tablet powder) with high sensitivity. In addition to its efficient extraction, the PEEK tube based SPME has chemical and mechanical stability under even harsh conditions.

Electrochemically modified carbon fibers were packed into polyether ether ketone (PEEK) tube and connect with HPLC system. Good stability and extraction efficiency over 300 fold have been obtained. Application in plasma samples exhibits high extraction efficiency, good reproducibility and recoveries.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (Grant nos. 81573384, 21375101 and 91417301), and Natural Science Foundation of Hubei (No. 2014CFA077).

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Authors and Affiliations

  1. Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Wuhan, 430071, China

    Xu Ling, Wenpeng Zhang & Zilin Chen

  2. Wuhan University School of Pharmaceutical Science, Wuhan, 430071, China

    Xu Ling, Wenpeng Zhang & Zilin Chen

  3. State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Beijing, 10080, China

    Xu Ling, Wenpeng Zhang & Zilin Chen

Authors
  1. Xu Ling
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  2. Wenpeng Zhang
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  3. Zilin Chen
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Correspondence to Zilin Chen.

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Ling, X., Zhang, W. & Chen, Z. Electrochemically modified carbon fiber bundles as selective sorbent for online solid-phase microextraction of sulfonamides. Microchim Acta 183, 813–820 (2016). https://doi.org/10.1007/s00604-015-1726-y

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  • DOI: https://doi.org/10.1007/s00604-015-1726-y

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