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A platinum wire coated with a composite consisting of poly pyrrole and poly(ɛ-caprolactone) for solid phase microextraction of the antidepressant imipramine prior to its determination via ion mobility spectrometry

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Abstract

A poly(ɛ-caprolactone) deposited on a platinum wire by electrochemical polymerization of pyrrole in the presence of poly(ɛ-caprolactone) is introduced for use in solid-phase microextraction. The resulting fibers were analyzed by FTIR and scanning electron microscopy and are found to be thermally stable up to 280 °C. They were applied to the direct solid-phase microextraction and subsequent ion mobility spectrometric determination of the anti-depressant imipramine. The extraction capability of the fibers was compared to polypyrrole fibers. The effect of four parameters on peak height was investigated by d-optimal experimental design. Under optimized conditions, the detection limits for imipramine are 0.23 μg⋅L−1 (in urine) and 0.45 μg⋅L−1 (in plasma). The intra-day and inter-day relative standard deviations obtained at 100 μg L−1, using a single fibre, were found to be 2.5 % and 3.1 %, respectively. The method was successfully applied to the analysis of imipramine in urine and plasma real samples showing recoveries from 105 to 120 % and 91 to 101 %, respectively.

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Acknowledgments

The authors gratefully acknowledge the Shahid Beheshti University Research Affairs for their support.

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Authors and Affiliations

  1. Faculty of Chemistry, Shahid Beheshti University, G. C, 1983969411, Tehran, Islamic Republic of Iran

    Mostafa Jafari & Homeira Ebrahimzadeh

  2. Department of polymer, Faculty of Chemistry, Shahid Beheshti University, G. C, 1983969411, Tehran, Iran

    Roya Sedghi

Authors
  1. Mostafa Jafari
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  2. Roya Sedghi
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  3. Homeira Ebrahimzadeh
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Correspondence to Homeira Ebrahimzadeh.

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Jafari, M., Sedghi, R. & Ebrahimzadeh, H. A platinum wire coated with a composite consisting of poly pyrrole and poly(ɛ-caprolactone) for solid phase microextraction of the antidepressant imipramine prior to its determination via ion mobility spectrometry. Microchim Acta 183, 805–812 (2016). https://doi.org/10.1007/s00604-015-1719-x

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