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Ultrasensitive non-enzymatic glucose sensing at near-neutral pH values via anodic stripping voltammetry using a glassy carbon electrode modified with Pt3Pd nanoparticles and reduced graphene oxide

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Abstract

We describe an anodic stripping voltammetric (ASV) method for glucose sensing that widely expands the typical amperometric i-t response of glucose sensors. The electrode is based on a working electrode consisting of a glassy carbon electrode modified with Pt-Pd nanoparticles (NPs; in an atomic ratio of 3:1) on a reduced graphene oxide (rGO) support. The material was prepared via the spontaneous redox reaction between rGO, PdCl4 2− and PtCl4 2− without any additional reductant or surfactant. Unlike known Pt-based sensors, the use of Pt3Pd NPs results in an ultrasensitive ASV approach for sensing glucose even at near-neutral pH values. If operated at a working voltage as low as 0.06 V (vs. SCE), the modified electrode can detect glucose in the 2 nM to 300 μM concentration range. The lowest detectable concentration is 2 nM which is much lower than the LODs obtained with other amperometric i-t type sensing approaches, most of which have LODs at a μM level. The sensor is not interfered by the presence of 0.1 M of NaCl.

We describe an anodic stripping voltammetric method for glucose sensing that widely expands the typical amperometric i-t response of glucose sensors (2 nM to 300 μM). The electrode is based on a glassy carbon electrode modified with Pt-Pd nanoparticles on a reduced graphene oxide (rGO) support.

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Acknowledgments

This research work was financially supported by the National Nature Scientific Foundation of China (21175112 and 21375112), which are gratefully acknowledged. Professor John Hodgkiss of The University of Hong Kong is thanked for his assistance with English.

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Authors and Affiliations

  1. Xiamen Huaxia College, Xiamen, 361024, China

    Li Zhao, Tingting Zhao & Qiuhong Yao

  2. MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China

    Genghuang Wu, Zhixiong Cai & Xi Chen

Authors
  1. Li Zhao
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  2. Genghuang Wu
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  3. Zhixiong Cai
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  4. Tingting Zhao
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  5. Qiuhong Yao
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  6. Xi Chen
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Corresponding author

Correspondence to Xi Chen.

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Zhao, L., Wu, G., Cai, Z. et al. Ultrasensitive non-enzymatic glucose sensing at near-neutral pH values via anodic stripping voltammetry using a glassy carbon electrode modified with Pt3Pd nanoparticles and reduced graphene oxide. Microchim Acta 182, 2055–2060 (2015). https://doi.org/10.1007/s00604-015-1555-z

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  • DOI: https://doi.org/10.1007/s00604-015-1555-z

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