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Electrochemical determination of dopamine using octahedral SnO2 nanocrystals bound to reduced graphene oxide nanosheets

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Abstract

Novel nanocomposites were prepared from graphene oxide (GO) and octahedral tin dioxide (SnO2) through a facile process that included synthesis of octahedral SnO2 and the reduction of GO with ascorbic acid. The morphology and structure of the nanocomposites were characterized by UV–vis spectroscopy, transmission electron microscopy, and Raman spectroscopy. The nanocomposites were placed on a glassy carbon electrode where they displayed excellent performance in terms of differential pulse voltammetric determination of dopamine (DA). This is attributed to (a) the synergetic interactions between reduced graphene oxide (r-GO) and octahedral SnO2, and (b) the presence of a large number of active sites on the nanocomposites surface. The sensor responds to DA in the concentration range of 0.08 to 30 μM, with a 6 nM detection limit if operated at 0.24 V (vs. Ag/AgCl). The modified electrode also widely suppresses the background current resulting from excess ascorbic acid and uric acids. The method was applied to the determination of DA in spiked human urine and gave satisfactory results, with recoveries in the range from 96.4 to 98.2 %.

Green and facile synthesis of reduced graphene oxide-octahedral SnO2 (r-GO-SnO2) nanocomposites for the sensitive and selective electrochemical detection of dopamine.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (21305122), the Natural Science Foundation of Jiangsu Province (BK20131218), the Opening Foundation of the State Key Laboratory of Analytical Chemistry for Life Science of Nanjing University (SKLACLS1312), and the Industry-University-Research Cooperative Innovation Foundation of Jiangsu Province (BY2014108-19, BY2014108-08).

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Authors and Affiliations

  1. College of Sciences, Nanjing Technology University, Nanjing, 211816, China

    Hong-Fei Ma & Ting-Ting Chen

  2. School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng, 224051, China

    Ting-Ting Chen, Yu Luo, Fen-Ying Kong, Da-He Fan, Hai-Lin Fang & Wei Wang

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  1. Hong-Fei Ma
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  2. Ting-Ting Chen
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  3. Yu Luo
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  4. Fen-Ying Kong
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  7. Wei Wang
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Correspondence to Fen-Ying Kong or Wei Wang.

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Ma, HF., Chen, TT., Luo, Y. et al. Electrochemical determination of dopamine using octahedral SnO2 nanocrystals bound to reduced graphene oxide nanosheets. Microchim Acta 182, 2001–2007 (2015). https://doi.org/10.1007/s00604-015-1521-9

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  • DOI: https://doi.org/10.1007/s00604-015-1521-9

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