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Facile one-step electrochemical fabrication of a non-enzymatic glucose-selective glassy carbon electrode modified with copper nanoparticles and graphene

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Abstract

We have developed a non-enzymatic glucose sensor by using a composite prepared from copper nanoparticles (CuNPs) and graphene which can be prepared by simple 1-step electrochemical reduction using graphene oxide (GO) and copper ion as the starting materials. The GO is electrochemically reduced to graphene at a voltage of −1.5 V, and this is accompanied by the simultaneous formation of CuNPs on the surface of the graphene. This novel nanocomposite combines the advantages of graphene and of CuNPs and displays good electrocatalytic activity toward glucose in alkaline media. The performance of the respective glucose electrode was evaluated by amperometric experiments and revealed a fast response (<2 s), a low detection limit (200 nM), and high sensitivity (607 μA mM−1). The sensor also exhibits good reproducibility and very good specificity for glucose over ascorbic acid, dopamine, uric acid, fructose, lactose and sucrose.

(A) CVs of Cu NPs/graphene electrode (a), graphene electrode (b),and Cu/GC electrode (c) in 0.1 M NaOH solution with 0.5 mM glucose; (B) The response of the Cu NPs/graphene electrode to successive addition of glucose from 5 μM to 0.2 mM.

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Acknowledgements

We acknowledge financial support from the National Natural Science Foundation of China (under Grant Nos. 21174056 and 51103064) and the Fundamental Research Funds for the Central Universities (JUSRP31003 and JUSRP11108).

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Authors and Affiliations

  1. The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi, 214122, China

    Jing Luo, Hongyan Zhang, Sisi Jiang, Jinqiang Jiang & Xiaoya Liu

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  1. Jing Luo
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  2. Hongyan Zhang
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  3. Sisi Jiang
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  4. Jinqiang Jiang
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  5. Xiaoya Liu
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Correspondence to Jing Luo or Xiaoya Liu.

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Luo, J., Zhang, H., Jiang, S. et al. Facile one-step electrochemical fabrication of a non-enzymatic glucose-selective glassy carbon electrode modified with copper nanoparticles and graphene. Microchim Acta 177, 485–490 (2012). https://doi.org/10.1007/s00604-012-0795-4

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