Abstract
A differential pulse voltammetric method was developed for the simultaneous determination of paracetamol, 4-aminophenol and dopamine at pH 7.0 using a glassy carbon electrode (GCE) coated with gold nanoparticles (AuNPs) and a layered double hydroxide sodium modified with dodecyl sulfate (SDS-LDH). The modified electrode displays excellent redox activity towards paracetamol, and the redox current is increased (and the corresponding over-potential decreased) compared to those of the bare GCE, the AuNPs-modified GCE, and the SDS-LDH-modified GCE. The modified electrode enables the determination of paracetamol in the concentration range from 0.5 to 400 μM, with a detection limit of 0.13 μM (at an S/N of 3). The sensor was successfully applied to the stimultaneous determination of paracetamol and dopamine, and of paracetamol and 4-aminophenol, respectively, in pharmaceutical tablets and in spiked human serum samples.
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Acknowledgement
The authors are grateful to the financial supports from the National Natural Science Foundation of China (No. 21075078) and the Natural Science Foundation of Shandong province, China (No. ZR2010BM005).
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Yin, H., Shang, K., Meng, X. et al. Voltammetric sensing of paracetamol, dopamine and 4-aminophenol at a glassy carbon electrode coated with gold nanoparticles and an organophillic layered double hydroxide. Microchim Acta 175, 39–46 (2011). https://doi.org/10.1007/s00604-011-0652-x
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DOI: https://doi.org/10.1007/s00604-011-0652-x