Mini-emulsion solvent evaporation: a simple and versatile way to magnetic nanosensors
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Magnetic optical sensor particles were prepared using a mini-emulsion solvent evaporation (MESE) technique. The resulting nanoparticles (NPs) have diameters around 100 nm and relatively narrow size distribution (PDI < 0.2). Incorporation of probes for oxygen or pH resulted in magnetic sensor particles for bioprocess monitoring and imaging applications. The MESE technique yields sensing NPs in higher quantities than obtained by a previously reported nanoprecipitation method, and the size of the NPs is smaller than that of particles made by spray-drying of sensor cocktails. Moreover, the technique is flexible in terms of polymers, solvents and indicators used in that it may be applied—at least in principle—to numerous combinations of two-phase systems.
KeywordsMagnetic optical sensor particles Oxygen sensor pH sensor Light harvesting Miniemulsion solvent evaporation Nanosensor
This work was supported by Österreichischer Austauschdienst, ÖAD (program Acciones Integradas) under the project number ES 13/2007. Further financial support was received from the Spanish Ministry of Education (FPU grant reference AP2006-01144) and the Regional Government of Andalusia (Excellence projects P07-FQM-02738 and P07-FQM-02625). We also thank Dr. Armin Zankel and Dr. Angelika Reichmann from the Institute for Electron Microscopy, Graz University of Technology, for the SEM measurements.
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