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A solid bar microextraction method for the liquid chromatographic determination of trace diclofenac, ibuprofen and carbamazepine in river water

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Abstract

A solid bar microextraction (SBME) method containing sorbent materials 2 mg in the lumen of a porous hollow fiber membrane 2.5 cm for the extraction of carbamazepine, diclofenac and ibuprofen from river water samples is described. The desorbed analytes were analyzed using reversed-phase high performance liquid chromatography with ultraviolet detection. In order to achieve optimum performance, several extraction parameters were optimized. Of the sorbents evaluated, LiChrosorb RP-8 was the most promising. Under the optimized conditions, limits of detection from 0.7 to 0.9 μg L−1, precisions from 5.5 to 6.4% and a correlation coefficient of 0.999 were obtained for the target drugs over a concentration range of 1–200 μg L−1. In comparison with the solid phase extraction, the SBME system offers distinct advantages due to its higher enrichment factors, lower consumption of organic solvents and time saving.

A solid bar microextraction method for the liquid chromatographic determination of trace diclofenac, ibuprofen and carbamazepine in river water

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Acknowledgements

Financial support of the work via a Universiti Sains Malaysia (USM) Research University Grant is acknowledged. One of us (Nabil AL-Hadithi) thanks USM for providing a postdoctoral research position.

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Authors and Affiliations

  1. School of Chemical Sciences, Universiti Sains Malaysia, 11800, Penang, Malaysia

    Nabil AL-Hadithi & Bahruddin Saad

  2. Department of Chemistry, University of Paderborn, Warburger Straβe 100, 33098, Paderborn, Germany

    Manfred Grote

Authors
  1. Nabil AL-Hadithi
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  2. Bahruddin Saad
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  3. Manfred Grote
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Correspondence to Nabil AL-Hadithi.

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AL-Hadithi, N., Saad, B. & Grote, M. A solid bar microextraction method for the liquid chromatographic determination of trace diclofenac, ibuprofen and carbamazepine in river water. Microchim Acta 172, 31–37 (2011). https://doi.org/10.1007/s00604-010-0463-5

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  • DOI: https://doi.org/10.1007/s00604-010-0463-5

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