Skip to main content

Advertisement

SpringerLink
Log in

Determination of diethylene glycol in toothpaste by capillary electrophoresis with electrochemical detection

  • Original Paper
  • Published:
Microchimica Acta Aims and scope Submit manuscript

Abstract

Diethylene glycol (DEG) can be determined in toothpaste via capillary electrophoresis at 16 kV using a fused silica capillary of 75 cm length and of 25 μm diameter along with a copper disc electrode detector operated at  + 0.65 V (vs. SCE). DEG, propylene glyco1 and glycerol in a running buffer of pH 9.2 were separated within 17 min. The linear range for DEG is from 840 to to 4.2 μg·mL−1, and the detection limit (at S/N = 3) is 1.6 μg·mL−1 which therefore meets the safety limit. When applied to the analysis of DEG in toothpaste, the recoveries are between 96.9 and 103.0% for spiked samples and thus are quite satisfactory.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig..3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Lewis RJ (1993) Hawley’s Condensed Chemical Dictionary. Van Nostrand Reinhold Company, New York, p 391

    Google Scholar 

  2. Lenk W, Lohr D, Sonnenbichler D (1989) Pharmacokinetics and biotransformation of diethylene glycol and ethylene glycol in the rat. Xenobiotica 9:961–979

    Article  Google Scholar 

  3. Weiner HL, Richardson KE (1989) Metabolism of diethylene glycol in male rats. Biochem Pharmacol 38:539–541

    Article  Google Scholar 

  4. Catherine JP, Kimmel CA, Julia DG, Melissa CM (1987) The developmental toxicity of diethylene glycol dimethyl ether in mice. Fundam Appl Toxicol 8(1):115–126

    Article  Google Scholar 

  5. Gaunt IF, Colley J, Grasso P, Lansdown ABG, Gangolli SD (1968) Short-term toxicity of diethylene glycol monoethyl ether in the rat, mouse and pig. Food Cosmet Toxicol 6(6):689–698

    Article  CAS  Google Scholar 

  6. Bryan B, Snellings WM (2005) Developmental toxicity study with diethylene glycol dosed by gavage to CD rats and CD-1 mice. Food Chem Toxicol 43:1637–1646

    Article  Google Scholar 

  7. American Industrial Hygiene Association (1999) Diethylene glycol. Workplace Environmental Exposure Level Guide. American Industrial Hygiene Association Press, Fairfax, pp 1–5

    Google Scholar 

  8. General Administration of Quality Supervision, Inspection and Quarantine of the People’s Republic of China. The prohibition of using diglycol as the raw material in toothpaste.

  9. Christopher RG, Cheri MB (2003) Identification of diethylene glycol monobutyl ether as a source of contamination in an ion trap mass spectrometer. J Am Soc Mass Spectrom 14(11):1247–1249

    Article  Google Scholar 

  10. Achille C, Giorgio F, Pierangela P, Elisabetta P, Helga T, Chiara M, Loredana M, Michela M (2007) Application of nano-FIA-Direct-EI-MS to determine diethylene glycol in produced formation water discharges and seawater samples. Chemosphere 69(4):554–560

    Article  Google Scholar 

  11. Richard JE, Peter RHJ, Norman MR, Peter TNS (2004) Identification by gas chromatography-mass spectrometry of the volatile organic compounds emitted from the wood-rotting fungi Serpula lacrymans and Coniophora puteana, and from Pinus sylvestris timber. Mycol Res 10(7):806–814

    Google Scholar 

  12. Hans HM, Frank TP, Liane DP, Thomas K (2001) Validated gas chromatographic–mass spectrometric assay for determination of the antifreezes ethylene glycol and diethylene glycol in human plasma after microwave-assisted pivalylation. J Chromatogr B: Biomed Sci Appl 754(2):401–409

    Article  Google Scholar 

  13. López-Sánchez M, Domínguez-Vidal A, Ayora-Cañada MJ, Molina-Díaz A (2008) Assessment of dentifrice adulteration with diethylene glycol by means of ATR-FTIR spectroscopy and chemometrics. Anal Chim Acta 620(1–2):113–119

    Article  Google Scholar 

  14. Tong KX, Jiang J, Li HY (2007) Determination of diethylene glycol in toothpaste by GC/MS. Chinese Analytical instrument 4:26–29

    Google Scholar 

  15. Li DH, Ying ZQ, Zhang HQ (2004) Determination of DEG in PEN by alcoholysis method. Synthetic Tech & Appl 19(3):58–60

    Google Scholar 

  16. Gao LY, Chu QC, Ye JN (2002) Determination of trans-resveratrol in wines, herbs and health food by capillary electrophoresis with electrochemical detection. Food Chem 78:255–260

    Article  CAS  Google Scholar 

  17. Zhang X, Cao YH, Ye JN (2001) Determination of lactose in sugar-free milk powder by capillary electrophoresis with electrochemical detection. Food Chem 72:385–388

    Article  CAS  Google Scholar 

  18. Xing XP, Cao YH (2007) Determination of 3-chloro-1, 2-propanediol in soy sauces by capillary electrophoresis with electrochemical detection. Food Control 18(2):167–172

    Article  CAS  Google Scholar 

  19. Ye JN, Baldwin RP (1993) Amperometric detection in capillary electrophoresis with normal size electrode. Anal Chem 65:3525–3527

    Article  CAS  Google Scholar 

  20. Ye JN, Baldwin RP (1994) Determination of carbohydrates, sugar acids and alditols by capillary electrophoresis and electrochemical detection at a copper electrode. J Chromatogr 687:141–148

    Article  CAS  Google Scholar 

  21. Fang XM, Xie ZY, Ye JN, Fang YZ (1996) Determination of glycerol and sorbitol in tooth paste by capillary zone electrophoresis with amperometric detection. Chinese J Chromatogr 14:467–469

    CAS  Google Scholar 

Download references

Acknowledgements

The authors are grateful for the financial supported by the National Science Foundation of China (grant No. 20875032), and the Basic Research Fund of the Technology Commission of Shanghai Municipality (grant No. 09JC1409300).

Author information

Authors and Affiliations

  1. Department of Chemistry, East China Normal University, 200062, Shanghai, China

    Xiaoping Xing, Xue Shi, Haitao Zhang, Weiyu Wang & Jiannong Ye

  2. Department of Science and Industry, Yancheng Institute of Technology, 224003, Yancheng, China

    Xiaoping Xing

Authors
  1. Xiaoping Xing
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xue Shi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Haitao Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Weiyu Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jiannong Ye
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jiannong Ye.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Xing, X., Shi, X., Zhang, H. et al. Determination of diethylene glycol in toothpaste by capillary electrophoresis with electrochemical detection. Microchim Acta 167, 297–302 (2009). https://doi.org/10.1007/s00604-009-0231-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00604-009-0231-6

Keywords

Search

Navigation