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A novel method for methimazole determination using CdSe quantum dots as fluorescence probes

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Abstract

A novel method has been developed for methimazole analysis based on the quenching of fluorescence emission from CdSe quantum dots by methimazole. Under optimum conditions, the calibration graph was linear over the range of 50 nM to 5 μM (r 2 = 0.990). The limit of detection (S/N = 3) was 30 nM. The R.S.D. for ten determinations of 500 nM methimazole was 3.4%. The method was applied to determine methimazole in tablets and rat urine, and the results were satisfactory, i.e. consistent with those of gas chromatography–mass spectrometry. The possible cause of fluorescence quenching is due to the exchange of surface capping organic molecules of quantum dots induced by methimazole.

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Acknowledgements

The authors gratefully acknowledge the support for this research provided by New Century Excellent Talents in Chinese Ministry of Education (NCET-05-0668), the National Natural Science Foundation of China (20675034), Program for academic pacesetter of Wuhan (200851430484).

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Authors and Affiliations

  1. College of Science, The State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, People’s Republic of China

    Fei Dong, Kewang Hu, Heyou Han & Jiangong Liang

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  1. Fei Dong
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  2. Kewang Hu
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  3. Heyou Han
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  4. Jiangong Liang
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Correspondence to Heyou Han.

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Dong, F., Hu, K., Han, H. et al. A novel method for methimazole determination using CdSe quantum dots as fluorescence probes. Microchim Acta 165, 195–201 (2009). https://doi.org/10.1007/s00604-008-0120-4

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  • DOI: https://doi.org/10.1007/s00604-008-0120-4

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