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Microfabrication of a new sensor based on silver and silicon nanomaterials, and its application to the enrichment and detection of bovine serum albumin via surface-enhanced Raman scattering

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Abstract

A microchannel with a length of 40 mm, a width of 65 μm and a depth of 35 μm was fabricated on Si wafer via wet etching. This channel, composed of a silicon nanowire array and silver nanoparticles, served to enrich and detect bovine serum albumin as it yielded strong surface-enhanced Raman scattering at concentrations as low as 1 pM. The silver nanoparticles played two important roles: catalysts in the wet etching to produce the silicon nanowire array, and surface enhancers in Raman detection.

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Acknowledgement

Financial support from the National Natural Science Foundation of China (20571001, 20704001), the Education Department (no. 2006KJ006TD) of Anhui Province and Anhui Provincial Natural Science Foundation (070414185) are appreciated.

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Authors and Affiliations

  1. Anhui Key Laboratory of Functional Molecular Solids, and College of Chemistry and Materials Science, Anhui Normal University, Wuhu, 241000, People’s Republic of China

    Mingwang Shao, Lei Lu, Hong Wang & Shizhong Luo

  2. Department of Physics and Materials Science, Center of Super-Diamond and Advanced Films (COSDAF), City University of Hong Kong, 83 Tat Chee Avenue, Kowloon Tong, Hong Kong SAR, China

    Dorothy Duo Duo Ma

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  1. Mingwang Shao
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  2. Lei Lu
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  3. Hong Wang
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  4. Shizhong Luo
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  5. Dorothy Duo Duo Ma
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Correspondence to Mingwang Shao.

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Shao, M., Lu, L., Wang, H. et al. Microfabrication of a new sensor based on silver and silicon nanomaterials, and its application to the enrichment and detection of bovine serum albumin via surface-enhanced Raman scattering. Microchim Acta 164, 157–160 (2009). https://doi.org/10.1007/s00604-008-0051-0

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  • DOI: https://doi.org/10.1007/s00604-008-0051-0

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