Skip to main content
SpringerLink
Log in

A biochemical sniffer-chip for convenient analysis of gaseous formaldehyde from timber materials

  • Original Paper
  • Published:
Microchimica Acta Aims and scope Submit manuscript

Abstract.

A biochemical gas-sensor (sniffer-chip) with formaldehyde dehydrogenase (FALDH) was developed for convenient analysis of gaseous formaldehyde with high gas-selectivity. The sniffer-chip for formaldehyde in the gas phase was constructed by immobilizing FALDH to a Pt-electrode coated hydrophilic PTFE membrane. The oxidation current of NADH produced by the enzymatic reactions was measured by amperometric analysis. The calibration range of the sniffer-chip for formaldehyde in the gas phase was from 40 to 2000 ppb, which encountered the maximum permissible concentration of formaldehyde vapor in the residential house (80 ppb) and formaldehyde detection limit for the human sense of smell (410 ppb). As the resident-environmental application, the sniffer-chip was possible to measure the formaldehyde concentration from some timber materials (3 kinds of interior timber and 2 kinds of exterior formwork timber) within 3 min. The calculated concentration value by a regression analysis was consistent with those of a commercially available gas sensor and a gas detector tube for formaldehyde. The FALDH sniffer-tip would be effective and convenient approach to detect and measure gaseous formaldehyde with high gas-selectivity at the residential atmosphere.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • T Yoshida (1996) Revision and trend measures of preventive a bad smell code N. T. S. Inc. Tokyo

    Google Scholar 

  • Y Yamaguchi H Okada (1999) ArticleTitleMethods for measurements of indoor air pollution by formaldehyde and volatile organic compounds in residential buildings Environ Measurement Technol 6 63

    Google Scholar 

  • Japan Environmental & Sanitary Center Ed (1980) A report of chemical malodor analysis (a study for the Japan Environmental Agency) 248–250

  • T Seiyama A Kato K Fujiishi M Nagatani (1962) ArticleTitleA new detector for gaseous components using semiconductive thin films Anal Chem 34 1502 Occurrence Handle10.1021/ac60191a001 Occurrence Handle1:CAS:528:DyaF38Xkslant78%3D

    Article  CAS  Google Scholar 

  • M Tonoike (1988) ArticleTitleCurrent status and future view of development for odorant sensors Bulletin Electrotech Lab 52 63

    Google Scholar 

  • Y Hiranaka T Abe H Murata (1992) ArticleTitleGas-dependent response in the temperature transient of SnO2 gas sensors Sens Actua B 9 177 Occurrence Handle10.1016/0925-4005(92)80213-H

    Article  Google Scholar 

  • T Maekawa J Tamaki N Miura N Yamazoe (1992) ArticleTitleDevelopment of SnO2-based ethanol gas sensor Sens Actua B 9 63 Occurrence Handle10.1016/0925-4005(92)80195-4

    Article  Google Scholar 

  • Z Chen K Colbow (1992) ArticleTitleMgO-doped Cr2O3: solubility limit and the effect of doping on the resistivity and ethanol sensitivity Sens Actua B 9 49 Occurrence Handle10.1016/0925-4005(92)80192-Z

    Article  Google Scholar 

  • X Wang S Yee P Carey (1993) ArticleTitleAn integrated array of multiple thin-film metal oxide sensors for quantification of individual components in organic vapor mixtures Sens Actua B 13–14 458 Occurrence Handle10.1016/0925-4005(93)85426-B

    Article  Google Scholar 

  • T Hyodo M Kohyama Y Shimizu M Egashira (2000) ArticleTitleAcetaldehyde sensing properties of oxide semiconductor gas sensor Chem Sens 16-A 10

    Google Scholar 

  • M J Dennison J M Hall A P F Turner (1996) ArticleTitleDirect monitoring of formaldehyde vapour and detection of ethanol vapour using dehydrogenase-based biosensors Analyst 121 1769 Occurrence Handle10.1039/an9962101769 Occurrence Handle1:CAS:528:DyaK2sXks1Sk

    Article  CAS  Google Scholar 

  • T Noguer J L Marty (1995) ArticleTitleAn amperometric bienzyme electrode for acetaldehyde detection Enzyme Microb Tech 17 453 Occurrence Handle10.1016/0141-0229(94)00068-3 Occurrence Handle1:CAS:528:DyaK2MXls1Sqt7Y%3D

    Article  CAS  Google Scholar 

  • T Noguer J L Marty (1997) ArticleTitleHigh sensitive bienzymic sensor for the detection of dithiocarbamate fungicides Anal Chim Acta 347 63 Occurrence Handle10.1016/S0003-2670(97)00127-X Occurrence Handle1:CAS:528:DyaK2sXksFKiu7w%3D

    Article  CAS  Google Scholar 

  • K Mitsubayashi K Yokoyama T Takeuchi I Karube (1994) ArticleTitleGas-phase biosensor for ethanol Anal Chem 66 3297 Occurrence Handle10.1021/ac00092a004 Occurrence Handle1:CAS:528:DyaK2cXlslagtrc%3D

    Article  CAS  Google Scholar 

  • K Mitsubayashi Y Hashimoto (2002) ArticleTitleBioelectronic sniffer device for trimethylamine vapor using flavin containing monooxygenase IEEE Sens J 2 133 Occurrence Handle10.1109/JSEN.2002.800283 Occurrence Handle1:CAS:528:DC%2BD38Xms1Ohtb0%3D

    Article  CAS  Google Scholar 

  • K Mitsubayashi Y Hashimoto (2002) ArticleTitleBioelectronic nose for methyl mercaptan vapor using xenobiotic metabolizing enzyme: flavin-containing monooxygenase Sens Actua B 83 35 Occurrence Handle10.1016/S0925-4005(01)01025-5

    Article  Google Scholar 

  • K Mitsubayashi K Nakayama M Taniguchi H Saito K Otsuka H Kudo (2006) ArticleTitleBioelectronic sniffer for nicotine using enzyme inhibition Anal Chim Acta 573–574 69 Occurrence Handle10.1016/j.aca.2006.01.091

    Article  Google Scholar 

  • K Mitsubayashi H Matsunaga G Nishio S Toda Y Nakanishi (2005) ArticleTitleBioelectronic sniffers for ethanol and acetaldehyde in breath air after drinking Biosens Bioelectron 20 1573 Occurrence Handle10.1016/j.bios.2004.08.007 Occurrence Handle1:CAS:528:DC%2BD2MXktVCn

    Article  CAS  Google Scholar 

  • K Mitsubayashi G Nishio Y Nakayama H Amagai H Watanabe N Jaffrezic-Renault T Noguer J L Marty (2005) ArticleTitleBioelectronic sniffers for formaldehyde in the gas phase Intern J Environ Anal Chem 85 917 Occurrence Handle10.1080/03067310500153793 Occurrence Handle1:CAS:528:DC%2BD2MXhtVWgtLvN

    Article  CAS  Google Scholar 

  • K Mitsubayashi K Yokoyama T Takeuchi E Tamiya I Karube (1993) ArticleTitleFlexible conductimetric sensor Anal Chem 65 3586 Occurrence Handle10.1021/ac00072a010 Occurrence Handle1:CAS:528:DyaK3sXmsVCku7Y%3D

    Article  CAS  Google Scholar 

  • K Ichimura (1984) ArticleTitleA convenient photochemical method to immobilize enzymes J Polym Sci 22 2817 Occurrence Handle1:CAS:528:DyaL2MXitVeltA%3D%3D

    CAS  Google Scholar 

  • J K Park H J Yee K S Lee W Y Lee M C Shin T H Kim S R Kim (1999) ArticleTitleDetermination of breath alcohol using a differential-type amperometric biosensor based on alcohol dehydrogenase Anal Chim Acta 390 83 Occurrence Handle10.1016/S0003-2670(99)00135-X Occurrence Handle1:CAS:528:DyaK1MXjtFKisrc%3D

    Article  CAS  Google Scholar 

  • Mitsubayashi K, Nishio G, Sawai M, Saito T, Kudo H, Saito H, Otsuka K, Noguer T, Marty J L (2007) Sens Actua B (submitted)

Download references

Author information

Authors and Affiliations

  1. Department of Biomedical Devices and Instrumentation, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Kanda-Surugadai, Chiyoda-ku, Tokyo, Japan

    Kohji Mitsubayashi, Takao Saito, Hiroyuki Kudo, Kimio Otsuka & Hirokazu Saito

  2. Graduate School of Engineering, Tokai University, Kitakaname, Hiratsuka, Kanagawa, Japan

    Genki Nishio, Masayuki Sawai & Motoharu Takao

  3. Tokyo Metropolitan Industrial Technology Research Institute, Nishigaoka, Kita-ku, Tokyo, Japan

    Elito Kazawa & Hiromichi Yoshida

Authors
  1. Kohji Mitsubayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Genki Nishio
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Masayuki Sawai
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Elito Kazawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hiromichi Yoshida
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Takao Saito
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hiroyuki Kudo
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Kimio Otsuka
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Motoharu Takao
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Hirokazu Saito
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kohji Mitsubayashi.

Additional information

Correspondence: Kohji Mitsubayashi, Department of Biomedical Devices and Instrumentation, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mitsubayashi, K., Nishio, G., Sawai, M. et al. A biochemical sniffer-chip for convenient analysis of gaseous formaldehyde from timber materials. Microchim Acta 160, 427–433 (2008). https://doi.org/10.1007/s00604-007-0799-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00604-007-0799-7

Search

Navigation