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Electrochemical determination of acetaminophen using a glassy carbon electrode coated with a single-wall carbon nanotube-dicetyl phosphate film

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Abstract.

Single-wall carbon nanotubes (SWNT) were dispersed into water in the presence of dicetyl phosphate (DCP), and then a SWNT-DCP film-coated glassy carbon electrode (GCE) was constructed. The electrochemical behavior of acetaminophen at bare GCE and SWNT-DCP modified GCE were compared, suggesting that the SWNT-DCP-modified GCE significantly enhances the oxidation peak current of acetaminophen. A sensitive and simple electrochemical method with a good linear relationship in the range of 1.0 × 10−7–2.0 × 10−5 mol L−1, was developed for the determination of acetaminophen. The detection limit is 4.0 × 10−8 mol L−1 for 3-min accumulation. This method was successfully demonstrated with tablets.

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Authors and Affiliations

  1. Department of Pharmacy, Wenzhou Medical College, 325000, Wenzhou, P.R. China

    Dong Sun & Huajie Zhang

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  1. Dong Sun
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  2. Huajie Zhang
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Correspondence to Dong Sun.

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Sun, D., Zhang, H. Electrochemical determination of acetaminophen using a glassy carbon electrode coated with a single-wall carbon nanotube-dicetyl phosphate film. Microchim Acta 158, 131–136 (2007). https://doi.org/10.1007/s00604-006-0691-x

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  • DOI: https://doi.org/10.1007/s00604-006-0691-x

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