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Selective determination of uric acid in the presence of ascorbic acid using a penicillamine self-assembled gold electrode

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Abstract.

The electrochemical behaviors of uric acid (UA) at the penicillamine (Pen) self-assembled monolayers modified gold electrode (Pen/Au) have been studied. The Pen/Au electrode is demonstrated to promote the electrochemical response of UA by cyclic voltammetry (CV). The diffusion coefficient D of UA is 6.97 × 10−6 cm2 s−1. In differential pulse voltammetric (DPV) measurements, the Pen/Au electrode can separate the UA and ascorbic acid (AA) oxidation potentials by about 120 mV and can be used for the selective determination of UA in the presence of AA. The detection limit was 1 × 10−6 mol L−1. The modified electrode shows excellent sensitivity, good selectivity and antifouling properties.

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Authors and Affiliations

  1. College of Life Science, Dalian Nationalities University, 116600, Dalian, China

    Liang Wang, Jun Yue Bai, Peng Fei Huang, Hong Jing Wang, Xiao Wei Wu & Yu Qing Zhao

  2. School of Environmental and Biological Science and Technology, Dalian University of Technology, 116024, Dalian, China

    Jun Yue Bai & Peng Fei Huang

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  1. Liang Wang
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  2. Jun Yue Bai
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  3. Peng Fei Huang
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  4. Hong Jing Wang
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  5. Xiao Wei Wu
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  6. Yu Qing Zhao
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Correspondence to Liang Wang.

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Wang, L., Bai, J., Huang, P. et al. Selective determination of uric acid in the presence of ascorbic acid using a penicillamine self-assembled gold electrode. Microchim Acta 158, 73–78 (2007). https://doi.org/10.1007/s00604-006-0656-0

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