Abstract
The effect of nutritional route on tumor necrosis factor α (TNF-α) production in burned rats was examined. Scald burns covering about 30% of the whole body surface area were inflicted on 43 male Wistar rats weighing about 200 g. The animals were divided into three groups: CHOW (n = 10), total parenteral nutrition (TPN) (n = 22), and total enteral nutrition (TEN) (n = 11), continuously given a chow diet, TPN solution, or an enteral diet, respectively, for 7 days after the burn injury. The rate of detection of TNF-α in plasma on day 7 was significantly higher in the TPN group than in the CHOW or TEN groups. The messenger RNA (mRNA) expression of TNF-α was significantly increased in the spleen, lungs, liver, and ileum of the rats receiving TPN compared with the CHOW and TEN rats. On the other hand, the expression of TNF-α mRNA was markedly decreased in the thymus of the TPN group compared with the CHOW group. The mortality rate in the TPN group (63.6%) was higher than that in the CHOW (0.0%) or TEN (27.3%) groups on day 7 after burn injury. These data suggest that TPN increases the expression of TNF-α mRNA in organ tissues and systemic TNF-α production, and reduces the survival rate of rats after thermal injury, but TEN does not.
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Received: May 15, 2000 / Accepted: November 20, 2000
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Cui, XL., Iwasa, M., Kuge, H. et al. Route of Feeding Influences the Production and Expression of Tumor Necrosis Factor α in Burned Rats. Surg Today 31, 615–625 (2001). https://doi.org/10.1007/s005950170096
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DOI: https://doi.org/10.1007/s005950170096