Abstract
We report herein the case of an 80-year-old woman with insulinoma who was regarded as an unsuitable candidate for immediate surgery due to her advanced age and obesity, for whom octreotide, a long-acting analogue of somatostatin, was used to improve her hypoglycemia and hyperinsulinemia without hyperalimentation. Administering a minimal dose of octreotide for a long period resulted in the improvement of leg edema, weight control, and cardiopulmonary function, and resection of the pancreatic tumor was safely carried out without any complications.
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References
Glaser B, Rosler A, Halperin Y (1990) Chronic treatment of a benign insulinoma using the long-acting somatostatin analogue SMS 201-995. Israel J Med Sci 26:16–19
Mignon M, Ruszniewski P, Podevin P, Sabbagh L, Cadiot G, Rigaud D, Bonfils S (1993) Current approach to the management of gastrinoma and insulinoma in adults with multiple endocrine neoplasia type I. World J Surg 17:489–497
Murakami S, Satomi A, Ishida K, Matsuki M, Koda H, Miura S (1995) Multiple endocrine neoplasia type 1 presenting as insulinoma, gastrinoma, and postbulbar duodenal ulcers: report of a case. Surg Today 25:848–851
Stehouwer CDA, Lems WF, Fischer HRA, Hackeng WHL, Naafs MAB (1989) Aggravation of hypoglycemia in patients by the long-acting somatostatin analogue octreotide. Acta Endocrinol 121:34–40
Von Eyben FE, Grodum E, Gjessing HJ, Hagen C, Nielsen HB (1994) Metabolic remission with octreotide in patients with insulinoma. J Intern Med 235:245–248
Jais P, Terris B, Ruszniewski P, LeRomancer M, Reyl Desmars F, Vissuzaine C, Cadiot G, Mignon M, Lewin MJ (1997) Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours. Eur J Clin Invest 27:639–644
Kisker O, Bartsch D, Weinel RJ, Joseph K, Welcke UH, Zaraca F, Rothmund M (1997) The value of somatostatin-receptor scintigraphy in newly diagnosed endocrine gastroenteropancreatic tumors. J Am Coll Surg 184:487–492
Kato M, Doi R, Imamaura M, Okada N, Shimada Y, Hosotani R, Miyazaki JI (1998) Response of human insulinoma cells to extracellular calcium is different from normal B cells. Dig Dis Sci 43:2429–2438
Sata N, Kimura W, Kanazawa T, Muto T (1995) Malignant insulinoma causing liver metastasis 8 years after the initial surgery: report of a case. Surg Today 25:640–642
Yoshitomi H, Fujii Y, Miyazaki M, Nakajima N, Inagaki N, Seino S (1997) Involvement of MAP kinase and c-fos signaling in the inhibition of cell growth by somatostatin. Am J Physiol 272:769–774
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Tanaka, Y., Funahashi, H., Imai, T. et al. The effectiveness of administering a minimal dose of octreotide long-term prior to surgery for insulinoma: Report of a case. Surg Today 30, 541–543 (2000). https://doi.org/10.1007/s005950070124
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DOI: https://doi.org/10.1007/s005950070124