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Nitrite/nitrate (NOx) levels and hemodynamics during septic shock

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Abstract

Nitric oxide (NO) acts as a vasorelaxant. We investigated the relationship between nitrite/nitrate (NOx), which are the final metabolites of NO, and hemodynamics during septic shock. We also examined tumor necrosis factor α (TNF-α), interleukin-8 (IL-8), and endotoxin. A significant negative correlation was observed between NOx levels and pulmonary capillary wedge pressure (PCWP;r=−0.6075,P=0.0028). A significant positive correlation was noted between NOx levels and the cardiac index (CI;r=−0.5934,P=0.0038). A significant negative correlation was found between NOx levels and the systemic vascular resistance index (SVRI;r=−0.4354,P=0.0485). A significant positive correlation was observed between NOx levels and the stroke volume index (SVI;r=0.5040,P=0.0186). A significantly close positive correlation was also observed between TNF-α levels and NOx levels (r=0.7848,P<0.0001). These findings suggest that NOx levels are closely associated with hemodynamics during septic shock, resulting in a vascular relaxing effect.

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Authors and Affiliations

  1. Critical Care and Emergency Center, Iwate Medical University, 19-1 Uchimaru, 020-8505, Morioka, Japan

    Hajime Nakae, Shigeatsu Endo, Mitsuru Kikuchi, Yasuhiko Yamada & Masashi Shibata

  2. Department of Emergency and Critical Care Medicine, Kansai Medical University, 10-12 Fumizonocho, Moriguchi, 570-0074, Osaka, Japan

    Hiroyasu Ishikura & Takaya Tanaka

  3. Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-0016, Tokyo, Japan

    Go Wakabayashi

  4. Memorial Heart Center, Iwate Medical University, 1-2-3 Chuodori, 020-0021, Morioka, Japan

    Takae Kawamura

  5. Department of Bacteriology, Iwate Medical University School of Medicine, 19-1 Uchimaru, 020-8505, Morioka, Japan

    Katsuya Inada & Seidai Sato

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  1. Hajime Nakae
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  2. Shigeatsu Endo
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  3. Mitsuru Kikuchi
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  4. Yasuhiko Yamada
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  6. Hiroyasu Ishikura
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  7. Takaya Tanaka
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  8. Go Wakabayashi
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  9. Takae Kawamura
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  10. Katsuya Inada
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  11. Seidai Sato
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Nakae, H., Endo, S., Kikuchi, M. et al. Nitrite/nitrate (NOx) levels and hemodynamics during septic shock. Surg Today 30, 683–688 (2000). https://doi.org/10.1007/s005950070078

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  • DOI: https://doi.org/10.1007/s005950070078

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