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Suppression of prostanoid formation and regulation of peripheral circulation after surgery using thrombin inhibitor (MD805)

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Abstract

We studied the effects of thrombin generation due to surgical stress on prostanoid formation and peripheral circulation in anesthetized dogs. Three experimental groups were used, consisting of a control group (group 1), a thoracotomized group (group 2), and a thoracotomized group treated with thrombin inhibitor (MD805: a synthetic arginine derivative) (group 3). The plasma concentrations of thrombin-antithrombin III complex (TAT) and prostanoids were measured along with the hemodynamic parameters. The plasma concentrations of TAT and thromboxane B2 significantly increased 1h after a thoracotomy in group 2. However, neither concentration increased after a thoracotomy in group 3. The flow ratio of the brachial and femoral arteries to cardiac output significantly decreased 1h after a thoracotomy in group 2. This study indicates that thromboxane A2 was thus synthesized by the stimulation of endogenous thrombin, while it also reduced the peripheral blood flow after surgery.

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Authors and Affiliations

  1. Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, 305, Tsukuba, Ibaraki, Japan

    Masataka Onizuka, Shigemi Ishikawa, Osamu Ishibashi, Michiharu Suga, Kiyofumi Mitsui & Toshio Mitsui

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  1. Masataka Onizuka
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  2. Shigemi Ishikawa
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  3. Osamu Ishibashi
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  4. Michiharu Suga
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  5. Kiyofumi Mitsui
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  6. Toshio Mitsui
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Onizuka, M., Ishikawa, S., Ishibashi, O. et al. Suppression of prostanoid formation and regulation of peripheral circulation after surgery using thrombin inhibitor (MD805). Surg Today 28, 618–625 (1998). https://doi.org/10.1007/s005950050194

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  • DOI: https://doi.org/10.1007/s005950050194

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