Abstract
The aim of this study was to investigate the expression of the immediate early genes (IEGs),c-fos andc-jun, in the rat kidney and liver in two types of hemorrhage shock/ resuscitation models. In the first group, hemorrhagic shock was induced by the withdrawal of blood through the carotid artery. A mean arterial blood pressure (MAP) of 40mmHg was maintained for 1h before blood was reperfused. In the second group, the MAP was maintained at the same level for 2 h. Animals were resuscitated with Ringer’s lactate solution. In the first group, a rapid and transient induction ofc-fos andc-jun mRNAs in both the liver and kidney was observed, peaking 0 to 2h after reperfusion. In the second group, a more protracted pattern of induction was evident in both organs. In both models, the induction ofc-fos mRNA was distinctly different in the liver and kidney. These results indicated, first, that with respect to IEG expression, organs respond differently to a systemic shock/resuscitation stimuli, and second, that alterations in the pattern of IEG expression might represent an indication of the degree of organ damage or the repair processes subsequent to hypotension/reperfusion.
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Saito, T., Matsumoto, I., Goto, S. et al. The differential induction of two immediate early genes,c-fos andc-jun, after systemic hypovolemic shock/resuscitation in the rat liver and kidney. Surg Today 28, 608–617 (1998). https://doi.org/10.1007/s005950050193
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DOI: https://doi.org/10.1007/s005950050193