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Acute effects of distal pancreatectomy on portal and peripheral blood insulin concentrations in patients undergoing total gastrectomy

Surgery Today volume 28, pages 363–366 (1998)Cite this article

Abstract

The influence of distal pancreatectomy on portal and peripheral blood immunoreactive insulin (IRI) and immunoreactive glucagon (IRG) concentrations was evaluated in patients undergoing total gastrectomy. There were 22 patients studied, 12 of whom did not undergo distal pancreatectomy (group 1), and 10 who did (group 2). In group 2, the increase in portal blood IRI concentrations after a glucose infusion of 25 g over 30min was suppressed, and reelevation of the portal blood IRG concentration after the glucose-induced depression was inhibited compared to group 1. In contrast, the peripheral blood IRI concentration did not reflect these changes in the portal blood IRI concentration. The rise in the arterial ketone body ratio (AKBR) and the fall in the total ketone body concentration after glucose infusion were also attenuated after distal pancreatectomy in group 2. These findings suggest that distal pancreatectomy has an immediate suppressive effect on the pancreatic secretion of insulin and glucagon, and might disturb metabolism in the liver.

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Authors and Affiliations

  1. Department of Anesthesia, Kanagawa Cancer Center Hospital, 1-1-2 Nakao, Asahi-ku, 241, Yokohama, Japan

    Jun Hayakawa

  2. Third Division of Surgery, Kanagawa Cancer Center Hospital, 1-1-2 Nakao, Asahi-ku, 241, Yokohama, Japan

    Akira Tsuburaya, Hisahiko Motohashi, Motonori Sairenji, Osamu Kobayashi & Kazufumi Suzuki

  3. Department of Anesthesiology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236, Yokohama, Japan

    Yutaka Usuda

Authors
  1. Jun Hayakawa
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  2. Akira Tsuburaya
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  3. Hisahiko Motohashi
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  4. Motonori Sairenji
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  5. Osamu Kobayashi
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  6. Kazufumi Suzuki
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  7. Yutaka Usuda
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Hayakawa, J., Tsuburaya, A., Motohashi, H. et al. Acute effects of distal pancreatectomy on portal and peripheral blood insulin concentrations in patients undergoing total gastrectomy. Surg Today 28, 363–366 (1998). https://doi.org/10.1007/s005950050142

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  • DOI: https://doi.org/10.1007/s005950050142

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